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Review

Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives

1
Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, 91220 Brétigny-sur-Orge, France
2
Clinical Unit Research, HIA Bégin, 94160 Saint-Mandé, France
3
Radiobiology of Medical Exposure Laboratory (LRMed), Institute for Radiological Protection and Nuclear Safety (IRSN), 92260 Fontenay-aux-Roses, France
4
Department of Urology, HIA Bégin, 94160 Saint-Mand, France
5
Gustave Roussy Comprehensive Cancer Center, Department of Radiation Oncology, 94805 Villejuif, France
6
French Military Health Academy, Ecole du Val-de-Grâce (EVDG), 75005 Paris, France
*
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 21; https://doi.org/10.3390/cells10010021
Received: 4 November 2020 / Revised: 10 December 2020 / Accepted: 22 December 2020 / Published: 24 December 2020
(This article belongs to the Special Issue Stem Cells and Irradiation)
Radiation cystitis is a potential complication following the therapeutic irradiation of pelvic cancers. Its clinical management remains unclear, and few preclinical data are available on its underlying pathophysiology. The therapeutic strategy is difficult to establish because few prospective and randomized trials are available. In this review, we report on the clinical presentation and pathophysiology of radiation cystitis. Then we discuss potential therapeutic approaches, with a focus on the immunopathological processes underlying the onset of radiation cystitis, including the fibrotic process. Potential therapeutic avenues for therapeutic modulation will be highlighted, with a focus on the interaction between mesenchymal stromal cells and macrophages for the prevention and treatment of radiation cystitis. View Full-Text
Keywords: radiation therapy; radiation cystitis; fibrosis; treatment; stem cells therapy; macrophages radiation therapy; radiation cystitis; fibrosis; treatment; stem cells therapy; macrophages
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MDPI and ACS Style

Helissey, C.; Cavallero, S.; Brossard, C.; Dusaud, M.; Chargari, C.; François, S. Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives. Cells 2021, 10, 21. https://doi.org/10.3390/cells10010021

AMA Style

Helissey C, Cavallero S, Brossard C, Dusaud M, Chargari C, François S. Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives. Cells. 2021; 10(1):21. https://doi.org/10.3390/cells10010021

Chicago/Turabian Style

Helissey, Carole, Sophie Cavallero, Clément Brossard, Marie Dusaud, Cyrus Chargari, and Sabine François. 2021. "Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives" Cells 10, no. 1: 21. https://doi.org/10.3390/cells10010021

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