Next Article in Journal
Calreticulin—Multifunctional Chaperone in Immunogenic Cell Death: Potential Significance as a Prognostic Biomarker in Ovarian Cancer Patients
Previous Article in Journal
Mono(ADP-ribosyl)ation Enzymes and NAD+ Metabolism: A Focus on Diseases and Therapeutic Perspectives
Previous Article in Special Issue
Laron Syndrome Research Paves the Way for New Insights in Oncological Investigation
Open AccessReview

Central Regulation of Metabolism by Growth Hormone

1
Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, Brazil
2
Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-900, Brazil
*
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 129; https://doi.org/10.3390/cells10010129
Received: 11 December 2020 / Revised: 4 January 2021 / Accepted: 5 January 2021 / Published: 11 January 2021
(This article belongs to the Special Issue GH and GHR Signaling in Disease and Health)
Growth hormone (GH) is secreted by the pituitary gland, and in addition to its classical functions of regulating height, protein synthesis, tissue growth, and cell proliferation, GH exerts profound effects on metabolism. In this regard, GH stimulates lipolysis in white adipose tissue and antagonizes insulin’s effects on glycemic control. During the last decade, a wide distribution of GH-responsive neurons were identified in numerous brain areas, especially in hypothalamic nuclei, that control metabolism. The specific role of GH action in different neuronal populations is now starting to be uncovered, and so far, it indicates that the brain is an important target of GH for the regulation of food intake, energy expenditure, and glycemia and neuroendocrine changes, particularly in response to different forms of metabolic stress such as glucoprivation, food restriction, and physical exercise. The objective of the present review is to summarize the current knowledge about the potential role of GH action in the brain for the regulation of different metabolic aspects. The findings gathered here allow us to suggest that GH represents a hormonal factor that conveys homeostatic information to the brain to produce metabolic adjustments in order to promote energy homeostasis. View Full-Text
Keywords: cytokines; energy balance; GH; glucose homeostasis; hypothalamus cytokines; energy balance; GH; glucose homeostasis; hypothalamus
Show Figures

Figure 1

MDPI and ACS Style

Donato, J., Jr.; Wasinski, F.; Furigo, I.C.; Metzger, M.; Frazão, R. Central Regulation of Metabolism by Growth Hormone. Cells 2021, 10, 129. https://doi.org/10.3390/cells10010129

AMA Style

Donato J Jr., Wasinski F, Furigo IC, Metzger M, Frazão R. Central Regulation of Metabolism by Growth Hormone. Cells. 2021; 10(1):129. https://doi.org/10.3390/cells10010129

Chicago/Turabian Style

Donato, Jose, Jr.; Wasinski, Frederick; Furigo, Isadora C.; Metzger, Martin; Frazão, Renata. 2021. "Central Regulation of Metabolism by Growth Hormone" Cells 10, no. 1: 129. https://doi.org/10.3390/cells10010129

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop