Stabilization of Inverse Miniemulsions by Silyl-Protected Homopolymers
AbstractInverse (water-in-oil) miniemulsions are an important method to encapsulate hydrophilic payloads such as oligonucleotides or peptides. However, the stabilization of inverse miniemulsions usually requires block copolymers that are difficult to synthesize and/or cannot be easily removed after transfer from a hydrophobic continuous phase to an aqueous continuous phase. We describe here a new strategy for the synthesis of a surfactant for inverse miniemulsions by radical addition–fragmentation chain transfer (RAFT) polymerization, which consists in a homopolymer with triisopropylsilyl protecting groups. The protecting groups ensure the efficient stabilization of the inverse (water-in-oil, w/o) miniemulsions. Nanocapsules can be formed and the protecting group can be subsequently cleaved for the re-dispersion of nanocapsules in an aqueous medium with a minimal amount of additional surfactant. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 2535 KB)
Share & Cite This Article
Wald, S.; Wurm, F.R.; Landfester, K.; Crespy, D. Stabilization of Inverse Miniemulsions by Silyl-Protected Homopolymers. Polymers 2016, 8, 303.
Wald S, Wurm FR, Landfester K, Crespy D. Stabilization of Inverse Miniemulsions by Silyl-Protected Homopolymers. Polymers. 2016; 8(8):303.Chicago/Turabian Style
Wald, Sarah; Wurm, Frederik R.; Landfester, Katharina; Crespy, Daniel. 2016. "Stabilization of Inverse Miniemulsions by Silyl-Protected Homopolymers." Polymers 8, no. 8: 303.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.