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Structural Properties and Antifungal Activity against Candida albicans Biofilm of Different Composite Layers Based on Ag/Zn Doped Hydroxyapatite-Polydimethylsiloxanes

National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor St. P.O. BOX MG 36, Magurele 077125, Romania
National Institute for Materials Physics, 405 A Atomistilor Street, P.O. Box MG 07, Magurele 077125, Romania
Faculty of Physics, University of Bucharest, 405 Atomistilor Street, P.O. Box MG1, Magurele 077125, Romania
Horiba Jobin Yvon S.A, 16-18, rue du Canal, Longjumeau Cedex 91165, France
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Polymers 2016, 8(4), 131;
Received: 29 February 2016 / Revised: 25 March 2016 / Accepted: 30 March 2016 / Published: 9 April 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
PDF [12033 KB, uploaded 9 April 2016]


Modern medicine is still struggling to find new and more effective methods for fighting off viruses, bacteria and fungi. Among the most dangerous and at times life-threatening fungi is Candida albicans. Our work is focused on surface and structural characterization of hydroxyapatite, silver doped hydroxyapatite and zinc doped hydroxyapatite deposited on a titanium substrate previously coated with polydimethylsiloxane (HAp-PDMS, Ag:HAp-PDMS, Zn:HAp-PDMS) by different techniques: Scanning Electron Microscopy (SEM), Glow Discharge Optical Emission Spectroscopy (GDOES) and Fourier Transform Infrared Spectroscopy (FTIR). The morphological studies revealed that the use of the PDMS polymer as an interlayer improves the quality of the coatings. The structural characterizations of the thin films revealed the basic constituents of both apatitic and PDMS structure. In addition, the GD depth profiles indicated the formation of a composite material as well as the successful embedding of the HAp, Zn:HAp and Ag:HAp into the polymer. On the other hand, in vitro evaluation of the antifungal properties of Ag:HAp-PDMS and Zn:HAp-PDMS demonstrated the fungicidal effects of Ag:HAp-PDMS and the potential antifungal effect of Zn:HAp-PDMS composite layers against C. albicans biofilm. The results acquired in this research complete previous research on the potential use of new complex materials produced by nanotechnology in biomedicine. View Full-Text
Keywords: composite layers; Ag/Zn doped hydroxyapatite; PDMS; C. albicans biofilm composite layers; Ag/Zn doped hydroxyapatite; PDMS; C. albicans biofilm

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Groza, A.; Ciobanu, C.S.; Popa, C.L.; Iconaru, S.L.; Chapon, P.; Luculescu, C.; Ganciu, M.; Predoi, D. Structural Properties and Antifungal Activity against Candida albicans Biofilm of Different Composite Layers Based on Ag/Zn Doped Hydroxyapatite-Polydimethylsiloxanes. Polymers 2016, 8, 131.

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