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Polymers 2016, 8(4), 130;

A Thixotropic Polyglycerol Sebacate-Based Supramolecular Hydrogel as an Injectable Drug Delivery Matrix

Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore
College of Chemistry, Jilin University, Changchun 130012, China
Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore
Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117583, Singapore
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 27 February 2016 / Revised: 22 March 2016 / Accepted: 25 March 2016 / Published: 7 April 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
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We have developed a “self-healing” polyglycerol sebacate—polyethylene glycol methyl ether methacrylate (PGS-PEGMEMA)/α-Cyclodextrin (αCD) hydrogel which could be sheared into a liquid during injection and has the potential to quickly “heal” itself back into gel post-injection. This hydrogel was shown to be biocompatible and biodegradable and therefore appropriate for use in vivo. Furthermore, the storage and loss moduli of the hydrogels could be tuned (by varying the concentration of αCD) between a fraction of a kPa to a few 100 kPa, a range that coincides with the moduli of cells and human soft tissues. This property would allow for this hydrogel to be used in vivo with maximal mechanical compatibility with human soft tissues. In vitro experiments showed that the hydrogel demonstrated a linear mass erosion profile and a biphasic drug (doxorubicin) release profile: Phase I was primarily driven by diffusion and Phase II was driven by hydrogel erosion. The diffusion mechanism was modeled with the First Order equation and the erosion mechanism with the Hopfenberg equation. This established fitting model could be used to predict releases with other drugs and estimate the composition of the hydrogel required to achieve a desired release rate. View Full-Text
Keywords: polyglycerol sebacate; shear-thinning; self-healing; injectable hydrogel; supramolecular polyglycerol sebacate; shear-thinning; self-healing; injectable hydrogel; supramolecular

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Ye, H.; Owh, C.; Jiang, S.; Ng, C.Z.Q.; Wirawan, D.; Loh, X.J. A Thixotropic Polyglycerol Sebacate-Based Supramolecular Hydrogel as an Injectable Drug Delivery Matrix. Polymers 2016, 8, 130.

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