Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering

Chen, Jun; Zhang, Di; Wu, Lin-Ping; Zhao, Ming

doi:10.3390/polym15092015

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Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering

by

Jun Chen

^1,2,

Di Zhang

²,

Lin-Ping Wu

^2,*

and

Ming Zhao

^1,*

¹

Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

²

Center for Chemical Biology and Drug Discovery, Laboratory of Computational Biomedicine, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

^*

Authors to whom correspondence should be addressed.

Polymers 2023, 15(9), 2015; https://doi.org/10.3390/polym15092015

Submission received: 16 December 2022 / Revised: 21 April 2023 / Accepted: 21 April 2023 / Published: 24 April 2023

(This article belongs to the Special Issue Biopolymer-Based Biomimetic Scaffolds)

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Abstract

Blood vessels not only transport oxygen and nutrients to each organ, but also play an important role in the regulation of tissue regeneration. Impaired or occluded vessels can result in ischemia, tissue necrosis, or even life-threatening events. Bioengineered vascular grafts have become a promising alternative treatment for damaged or occlusive vessels. Large-scale tubular grafts, which can match arteries, arterioles, and venules, as well as meso- and microscale vasculature to alleviate ischemia or prevascularized engineered tissues, have been developed. In this review, materials and techniques for engineering tubular scaffolds and vasculature at all levels are discussed. Examples of vascularized tissue engineering in bone, peripheral nerves, and the heart are also provided. Finally, the current challenges are discussed and the perspectives on future developments in biofunctional engineered vessels are delineated.

Keywords: engineered vascular grafts; vasculature; vascularized tissue engineering; vascularization

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MDPI and ACS Style

Chen, J.; Zhang, D.; Wu, L.-P.; Zhao, M. Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering. Polymers 2023, 15, 2015. https://doi.org/10.3390/polym15092015

AMA Style

Chen J, Zhang D, Wu L-P, Zhao M. Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering. Polymers. 2023; 15(9):2015. https://doi.org/10.3390/polym15092015

Chicago/Turabian Style

Chen, Jun, Di Zhang, Lin-Ping Wu, and Ming Zhao. 2023. "Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering" Polymers 15, no. 9: 2015. https://doi.org/10.3390/polym15092015

APA Style

Chen, J., Zhang, D., Wu, L.-P., & Zhao, M. (2023). Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering. Polymers, 15(9), 2015. https://doi.org/10.3390/polym15092015

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering

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