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Review

New Insights of Scaffolds Based on Hydrogels in Tissue Engineering

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Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 011061 Bucharest, Romania
2
Academy of Romanian Scientists, 54 Independentei, 050094 Bucharest, Romania
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National Research Center for Micro and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
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Research Institute of the University of Bucharest (ICUB), University of Bucharest, 050657 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Ángel Serrano-Aroca
Polymers 2022, 14(4), 799; https://doi.org/10.3390/polym14040799
Received: 26 January 2022 / Revised: 11 February 2022 / Accepted: 16 February 2022 / Published: 18 February 2022
(This article belongs to the Special Issue Advanced Biodegradable Polymer Scaffolds for Tissue Engineering)
In recent years, biomaterials development and characterization for new applications in regenerative medicine or controlled release represent one of the biggest challenges. Tissue engineering is one of the most intensively studied domain where hydrogels are considered optimum applications in the biomedical field. The delicate nature of hydrogels and their low mechanical strength limit their exploitation in tissue engineering. Hence, developing new, stronger, and more stable hydrogels with increased biocompatibility, is essential. However, both natural and synthetic polymers possess many limitations. Hydrogels based on natural polymers offer particularly high biocompatibility and biodegradability, low immunogenicity, excellent cytocompatibility, variable, and controllable solubility. At the same time, they have poor mechanical properties, high production costs, and low reproducibility. Synthetic polymers come to their aid through superior mechanical strength, high reproducibility, reduced costs, and the ability to regulate their composition to improve processes such as hydrolysis or biodegradation over variable periods. The development of hydrogels based on mixtures of synthetic and natural polymers can lead to the optimization of their properties to obtain ideal scaffolds. Also, incorporating different nanoparticles can improve the hydrogel’s stability and obtain several biological effects. In this regard, essential oils and drug molecules facilitate the desired biological effect or even produce a synergistic effect. This study’s main purpose is to establish the main properties needed to develop sustainable polymeric scaffolds. These scaffolds can be applied in tissue engineering to improve the tissue regeneration process without producing other side effects to the environment. View Full-Text
Keywords: hydrogels; scaffolds; polymers; tissue engineering; healing process; regeneration hydrogels; scaffolds; polymers; tissue engineering; healing process; regeneration
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MDPI and ACS Style

Radulescu, D.-M.; Neacsu, I.A.; Grumezescu, A.-M.; Andronescu, E. New Insights of Scaffolds Based on Hydrogels in Tissue Engineering. Polymers 2022, 14, 799. https://doi.org/10.3390/polym14040799

AMA Style

Radulescu D-M, Neacsu IA, Grumezescu A-M, Andronescu E. New Insights of Scaffolds Based on Hydrogels in Tissue Engineering. Polymers. 2022; 14(4):799. https://doi.org/10.3390/polym14040799

Chicago/Turabian Style

Radulescu, Denisa-Maria, Ionela A. Neacsu, Alexandru-Mihai Grumezescu, and Ecaterina Andronescu. 2022. "New Insights of Scaffolds Based on Hydrogels in Tissue Engineering" Polymers 14, no. 4: 799. https://doi.org/10.3390/polym14040799

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