Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability

Elmowafy, Mohammed; Musa, Arafa; Alnusaire, Taghreed S.; Shalaby, Khaled; Fouda, Maged M. A.; Salama, Ayman; Al-Sanea, Mohammad M.; Abdelgawad, Mohamed A.; Gamal, Mohammed; Fouad, Shahinaze A.

doi:10.3390/polym13111808

Open AccessArticle

Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability

by

Mohammed Elmowafy

^1,2,*

,

Arafa Musa

^3,4,*,

Taghreed S. Alnusaire

⁵,

Khaled Shalaby

^1,2,

Maged M. A. Fouda

^5,6,

Ayman Salama

^2,7,

Mohammad M. Al-Sanea

⁸

,

Mohamed A. Abdelgawad

^8,9

,

Mohammed Gamal

¹⁰

and

Shahinaze A. Fouad

¹¹

¹

Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia

²

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11765, Egypt

³

Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia

⁴

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo 11371, Egypt

⁵

Biology Department, College of Science, Jouf University, Sakaka 72341, Saudi Arabia

⁶

Department of Zoology, Faculty of Science, Al-Azhar University, Assiut 71511, Egypt

⁷

Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, Tabuk 47711, Saudi Arabia

⁸

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia

⁹

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt

¹⁰

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt

¹¹

Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, Giza 14756, Egypt

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Polymers 2021, 13(11), 1808; https://doi.org/10.3390/polym13111808

Submission received: 28 April 2021 / Revised: 24 May 2021 / Accepted: 28 May 2021 / Published: 31 May 2021

(This article belongs to the Special Issue Biopolymers for Tissue Engineering)

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Abstract

The main objective of this study was to prepare and characterize oleogel as potential carrier for quercetin skin delivery. The formulations were prepared by adding olive oil (5–30%) to Pluronic F127 hydrogel and were evaluated for particle size, zeta potential, viscosity in vitro quercetin release and stability, and were compared with that of Pluronic F127 hydrogel. The selected formulation was characterized for its interaction possibility, ex vivo skin permeation and skin histological changes and safety. The particle sizes ranged from 345.3 ± 5.3 nm to 401.5 ± 2.8 nm, and possessed negative charges. The viscosities of the formulations were found in the range of 6367–4823 cps with inverse proportionality to olive oil percentage while the higher percentages showed higher quercetin release. Percentages of 25% and 30% olive oil showed instability pattern under the conditions of accelerated stability studies. Differential scanning calorimetry verified the existence of quercetin in micellar aggregation and the network in the case of hydrogel and oleogel respectively. Ex vivo skin permeation showed an improved skin permeation of quercetin when 20% olive oil containing oleogel was used. Skin histology after 10 days of application showed stratum corneum disruption and good safety profile. Based on these findings, the proposed oleogel containing 20% olive oil denotes a potential carrier for topical delivery of quercetin.

Keywords: oleogel; skin delivery; quercetin; olive oil

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MDPI and ACS Style

Elmowafy, M.; Musa, A.; Alnusaire, T.S.; Shalaby, K.; Fouda, M.M.A.; Salama, A.; Al-Sanea, M.M.; Abdelgawad, M.A.; Gamal, M.; Fouad, S.A. Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability. Polymers 2021, 13, 1808. https://doi.org/10.3390/polym13111808

AMA Style

Elmowafy M, Musa A, Alnusaire TS, Shalaby K, Fouda MMA, Salama A, Al-Sanea MM, Abdelgawad MA, Gamal M, Fouad SA. Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability. Polymers. 2021; 13(11):1808. https://doi.org/10.3390/polym13111808

Chicago/Turabian Style

Elmowafy, Mohammed, Arafa Musa, Taghreed S. Alnusaire, Khaled Shalaby, Maged M. A. Fouda, Ayman Salama, Mohammad M. Al-Sanea, Mohamed A. Abdelgawad, Mohammed Gamal, and Shahinaze A. Fouad. 2021. "Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability" Polymers 13, no. 11: 1808. https://doi.org/10.3390/polym13111808

APA Style

Elmowafy, M., Musa, A., Alnusaire, T. S., Shalaby, K., Fouda, M. M. A., Salama, A., Al-Sanea, M. M., Abdelgawad, M. A., Gamal, M., & Fouad, S. A. (2021). Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability. Polymers, 13(11), 1808. https://doi.org/10.3390/polym13111808

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Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability

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