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Open AccessArticle

Collagen Scaffolds Containing Hydroxyapatite-CaO Fiber Fragments for Bone Tissue Engineering

Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 333323, Taiwan
Department of Periodontics, Chang Gung Memorial Hospital, Taipei 105406, Taiwan
Department of Bioscience and Biotechnology, National Taiwan Ocean University; Keelung City 202301, Taiwan
Author to whom correspondence should be addressed.
Polymers 2020, 12(5), 1174;
Received: 30 April 2020 / Revised: 14 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
Collagen (COL) and hydroxyapatite (HAp) are the major components of bone, therefore, COL-HAp composites have been widely used as bone substitutes to promote bone regeneration. We have reported that HAp-CaO fibers (HANFs), which were fabricated by a sol-gel route followed by an electrospinning technique, possessed good drug-loading efficiency and limited the burst release of tetracycline. In the present study, we used HANF fragments to evaluate the effects of COL-HANF scaffolds on MG63 osteoblast-like cell behaviors. COL-HANF composite scaffolds in which the average diameter of HANFs was approximately 461 ± 186 nm were fabricated by a freeze-drying process. The alkaline phosphatase activity and the protein expression levels of OCN and BSP showed that compared with COL alone, the COL-HANF scaffold promoted the differentiation of MG63 osteoblast-like cells. In addition, the bone regeneration ability of the COL-HANF scaffold was examined by using a rabbit condylar defect model in vivo. The COL-HANF scaffold was biodegradable and promoted bone regeneration eight weeks after the operation. Hence, we concluded that the COL-HANF scaffold has potential as a bone graft for bone tissue engineering. View Full-Text
Keywords: collagen; hydroxyapatite; fiber fragments; composite; scaffold; bone regeneration collagen; hydroxyapatite; fiber fragments; composite; scaffold; bone regeneration
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MDPI and ACS Style

Tsai, S.-W.; Huang, S.-S.; Yu, W.-X.; Hsu, Y.-W.; Hsu, F.-Y. Collagen Scaffolds Containing Hydroxyapatite-CaO Fiber Fragments for Bone Tissue Engineering. Polymers 2020, 12, 1174.

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