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Open AccessArticle

Collagen Scaffolds Containing Hydroxyapatite-CaO Fiber Fragments for Bone Tissue Engineering

1
Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 333323, Taiwan
2
Department of Periodontics, Chang Gung Memorial Hospital, Taipei 105406, Taiwan
3
Department of Bioscience and Biotechnology, National Taiwan Ocean University; Keelung City 202301, Taiwan
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(5), 1174; https://doi.org/10.3390/polym12051174
Received: 30 April 2020 / Revised: 14 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
Collagen (COL) and hydroxyapatite (HAp) are the major components of bone, therefore, COL-HAp composites have been widely used as bone substitutes to promote bone regeneration. We have reported that HAp-CaO fibers (HANFs), which were fabricated by a sol-gel route followed by an electrospinning technique, possessed good drug-loading efficiency and limited the burst release of tetracycline. In the present study, we used HANF fragments to evaluate the effects of COL-HANF scaffolds on MG63 osteoblast-like cell behaviors. COL-HANF composite scaffolds in which the average diameter of HANFs was approximately 461 ± 186 nm were fabricated by a freeze-drying process. The alkaline phosphatase activity and the protein expression levels of OCN and BSP showed that compared with COL alone, the COL-HANF scaffold promoted the differentiation of MG63 osteoblast-like cells. In addition, the bone regeneration ability of the COL-HANF scaffold was examined by using a rabbit condylar defect model in vivo. The COL-HANF scaffold was biodegradable and promoted bone regeneration eight weeks after the operation. Hence, we concluded that the COL-HANF scaffold has potential as a bone graft for bone tissue engineering. View Full-Text
Keywords: collagen; hydroxyapatite; fiber fragments; composite; scaffold; bone regeneration collagen; hydroxyapatite; fiber fragments; composite; scaffold; bone regeneration
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MDPI and ACS Style

Tsai, S.-W.; Huang, S.-S.; Yu, W.-X.; Hsu, Y.-W.; Hsu, F.-Y. Collagen Scaffolds Containing Hydroxyapatite-CaO Fiber Fragments for Bone Tissue Engineering. Polymers 2020, 12, 1174.

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