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Open AccessArticle

Nanocomposite Cryogel Carriers from 2-Hydroxyethyl Cellulose Network and Cannabidiol-Loaded Polymeric Micelles for Sustained Topical Delivery

1
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria
2
Lab for Experimental Chemotherapy, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria
3
PBG GLOBAL LTD., Byalo Pole st. 3, 1618 Sofia, Bulgaria
4
Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(5), 1172; https://doi.org/10.3390/polym12051172
Received: 23 April 2020 / Revised: 12 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
(This article belongs to the Section Biobased and Biodegradable Polymers)
In this contribution, we report the development of original nanocomposite cryogels for sustained topical delivery of hydrophobic natural active substances such as cannabidiol (CBD). The cryogels were fabricated by a method involving cryogenic treatment and photo-crosslinking of aqueous systems containing biodegradable 2-hydroxyethyl cellulose (HEC) and CBD-loaded polymeric micelles. The preparation of the water-soluble form of CBD was a key element for the successful drug loading in the one-pot reaction. The main physical, mechanical and biological characteristics of CBD-loaded and blank cryogels such as gel fraction yield, swelling degree, morphology, storage and loss moduli, and cytotoxicity were studied in detail. The advantage of nanocomposite over pure HEC cryogel carriers in terms of achieving a sustained release profile was also demonstrated. View Full-Text
Keywords: cannabidiol; cryogels; polysaccharides; micelles; drug delivery cannabidiol; cryogels; polysaccharides; micelles; drug delivery
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MDPI and ACS Style

Momekova, D.; Ivanov, E.; Konstantinov, S.; Ublekov, F.; Petrov, P.D. Nanocomposite Cryogel Carriers from 2-Hydroxyethyl Cellulose Network and Cannabidiol-Loaded Polymeric Micelles for Sustained Topical Delivery. Polymers 2020, 12, 1172.

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