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Volume 12
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10.3390/polym12040940
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Article

A Multimodal Stimulation Cell Culture Bioreactor for Tissue Engineering: A Numerical Modelling Approach

by
João Meneses
1,2,
João C. Silva
3,
Sofia R. Fernandes
1,2,
Abhishek Datta
4,5,
Frederico Castelo Ferreira
3,
Carla Moura
1,
Sandra Amado
1,
Nuno Alves
1 and
Paula Pascoal-Faria
1,*
1
Centre for Rapid and Sustainable Product Development (CDRSP-IPLeiria), 2430-028 Marinha Grande, Portugal
2
Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal
3
Department of Bioengineering and iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
4
Soterix Medical, Inc., New York, NY 10001, USA
5
Department of Biomedical Engineering, City College of New York, New York, NY 10031, USA
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(4), 940; https://doi.org/10.3390/polym12040940
Submission received: 12 March 2020 / Revised: 2 April 2020 / Accepted: 11 April 2020 / Published: 18 April 2020
(This article belongs to the Section Polymer Applications)
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Abstract

The use of digital twins in tissue engineering (TE) applications is of paramount importance to reduce the number of in vitro and in vivo tests. To pursue this aim, a novel multimodal bioreactor is developed, combining 3D design with numerical stimulation. This approach will facilitate the reproducibility between studies and the platforms optimisation (physical and digital) to enhance TE. The new bioreactor was specifically designed to be additive manufactured, which could not be reproduced with conventional techniques. Specifically, the design suggested allows the application of dual stimulation (electrical and mechanical) of a scaffold cell culture. For the selection of the most appropriate material for bioreactor manufacturing several materials were assessed for their cytotoxicity. Numerical modelling methods were then applied to the new bioreactor using one of the most appropriate material (Polyethylene Terephthalate Glycol-modified (PETG)) to find the optimal stimulation input parameters for bone TE based on two reported in vitro studies.
Keywords: cylindrical perfusion bioreactor; multimodal stimulation; cytotoxicity study; material characterization; bone tissue engineering; finite element analysis; electrical stimulation cylindrical perfusion bioreactor; multimodal stimulation; cytotoxicity study; material characterization; bone tissue engineering; finite element analysis; electrical stimulation

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MDPI and ACS Style

Meneses, J.; C. Silva, J.; R. Fernandes, S.; Datta, A.; Castelo Ferreira, F.; Moura, C.; Amado, S.; Alves, N.; Pascoal-Faria, P. A Multimodal Stimulation Cell Culture Bioreactor for Tissue Engineering: A Numerical Modelling Approach. Polymers 2020, 12, 940. https://doi.org/10.3390/polym12040940

AMA Style

Meneses J, C. Silva J, R. Fernandes S, Datta A, Castelo Ferreira F, Moura C, Amado S, Alves N, Pascoal-Faria P. A Multimodal Stimulation Cell Culture Bioreactor for Tissue Engineering: A Numerical Modelling Approach. Polymers. 2020; 12(4):940. https://doi.org/10.3390/polym12040940

Chicago/Turabian Style

Meneses, João, João C. Silva, Sofia R. Fernandes, Abhishek Datta, Frederico Castelo Ferreira, Carla Moura, Sandra Amado, Nuno Alves, and Paula Pascoal-Faria. 2020. "A Multimodal Stimulation Cell Culture Bioreactor for Tissue Engineering: A Numerical Modelling Approach" Polymers 12, no. 4: 940. https://doi.org/10.3390/polym12040940

APA Style

Meneses, J., C. Silva, J., R. Fernandes, S., Datta, A., Castelo Ferreira, F., Moura, C., Amado, S., Alves, N., & Pascoal-Faria, P. (2020). A Multimodal Stimulation Cell Culture Bioreactor for Tissue Engineering: A Numerical Modelling Approach. Polymers, 12(4), 940. https://doi.org/10.3390/polym12040940

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