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Open AccessArticle

Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril

1
School of Chemistry and Chemical Engineering, Key Laboratory of Special Functional Aggregated Materials, Key Laboratory of Colloid and Interface Chemistry, Ministry Education, Shandong University, Jinan 250100, China
2
School of Light Industry and Engineering, Qilu University of Technology, Jinan 250353, China
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(9), 1470; https://doi.org/10.3390/polym11091470
Received: 28 July 2019 / Revised: 30 August 2019 / Accepted: 3 September 2019 / Published: 9 September 2019
(This article belongs to the Special Issue Self-assembly of Block Copolymers)
There is an urgent need for new strategies that allow the simultaneous detection and control of drug delivery. By making use of supramolecular host-guest interactions, a kind of pseudopolyrotaxanes, as a visualizable nanoscale drug carrier has been constructed by self-assembly of cucurbit[7]uril (CB[7]) with methoxy poly(ethylene glycol)-block-quaternized poly(4-vinyl pyridine) (mPEG-b-QP4VP) using 4-(chloromethyl)benzonitrile. Simple addition of CB[7] into an aqueous solution of mPEG-b-QP4VP resulted in noncovalent attachment of CB[7] to 4-cyanobenzyl-containing polymers, transforming the nonemissive mPEG-b-QP4VP micelles into highly fluorescent micelles. These pseudopolyrotaxanes micelles exhibited remarkable supramolecular assembly-induced emission enhancement and excellent biocompatibility, showing great potential for bioimaging applications. In addition, the efficient cellular uptake of the developed pseudopolyrotaxanes micelles loaded with the anticancer drug doxorubicin was a promising platform for simultaneous cell imaging and drug delivery, thereby widening their application in cancer theranostics. View Full-Text
Keywords: supramolecular chemistry; host-guest system; self-assembly; aggregation-induced emission; cell imaging; drug delivery supramolecular chemistry; host-guest system; self-assembly; aggregation-induced emission; cell imaging; drug delivery
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MDPI and ACS Style

Qiu, X.; Wang, X.; Hou, S.; Zhang, J.; Zhou, J.; Tan, Y. Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril. Polymers 2019, 11, 1470.

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