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Polymers 2018, 10(8), 830; https://doi.org/10.3390/polym10080830

Stimuli-Responsive Polypeptides for Biomedical Applications

Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
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Received: 6 July 2018 / Revised: 23 July 2018 / Accepted: 23 July 2018 / Published: 27 July 2018
(This article belongs to the Special Issue Polymeric Micro/Nanoparticles for Bio-Medical Applications)
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Abstract

Stimuli-responsive polypeptides have gained attention because desirable bioactive properties can be easily imparted to them while keeping their biocompatibility and biodegradability intact. In this review, we summarize the most recent advances in various stimuli-responsive polypeptides (pH, reduction, oxidation, glucose, adenosine triphosphate (ATP), and enzyme) over the past five years. Various synthetic strategies exploited for advanced polypeptide-based materials are introduced, and their applicability in biomedical fields is discussed. The recent polypeptides imparted with new stimuli-responsiveness and their novel chemical and physical properties are explained in this review. View Full-Text
Keywords: stimuli-responsiveness; polypeptides-based materials; drug and gene delivery systems stimuli-responsiveness; polypeptides-based materials; drug and gene delivery systems
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lee, D.; Rejinold, N.S.; Jeong, S.D.; Kim, Y.-C. Stimuli-Responsive Polypeptides for Biomedical Applications. Polymers 2018, 10, 830.

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