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Article

Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery

1
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea
2
Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad 45650, Pakistan
3
Department of Material Engineering, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad 45650, Pakistan
4
Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Polymers 2018, 10(4), 390; https://doi.org/10.3390/polym10040390
Received: 20 February 2018 / Revised: 27 March 2018 / Accepted: 28 March 2018 / Published: 1 April 2018
(This article belongs to the Special Issue Polymeric Micro/Nanoparticles for Bio-Medical Applications)
Hypoxia, or low oxygen tension, is a common feature of solid tumors. Here, we report hypoxia-responsive mesoporous silica nanoparticles (HR-MSNs) with a 4-nitroimidazole-β-cyclodextrin (NI-CD) complex that is acting as the hypoxia-responsive gatekeeper. When these CD-HR-MSNs encountered a hypoxic environment, the nitroimidazole (NI) gatekeeper portion of CD-HR-MSNs disintegrated through bioreduction of the hydrophobic NI state to the hydrophilic NI state. Under hypoxic conditions, the release rate of doxorubicin (DOX) from DOX-loaded CD-HR-MSNs (DOX-CD-HR-MSNs) increased along with the disintegration of the gatekeeper. Conversely, DOX release was retarded under normoxic conditions. In vitro experiments confirmed that DOX-CD-HR-MSNs exhibit higher toxicity to hypoxic cells when compared to normoxic cells. Confocal microscopy images indicated that DOX-CD-HR-MSNs effectively release DOX into SCC-7 cells under hypoxic conditions. These results demonstrate that CD-HR-MSNs can release drugs in a hypoxia-responsive manner, and thus are promising drug carriers for hypoxia-targeted cancer therapy. View Full-Text
Keywords: hypoxia; mesoporous silica nanoparticles; nitroimidazole; β-cyclodextrin; doxorubicin hypoxia; mesoporous silica nanoparticles; nitroimidazole; β-cyclodextrin; doxorubicin
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MDPI and ACS Style

Khatoon, S.; Han, H.S.; Jeon, J.; Rao, N.V.; Jeong, D.-W.; Ikram, M.; Yasin, T.; Yi, G.-R.; Park, J.H. Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery. Polymers 2018, 10, 390. https://doi.org/10.3390/polym10040390

AMA Style

Khatoon S, Han HS, Jeon J, Rao NV, Jeong D-W, Ikram M, Yasin T, Yi G-R, Park JH. Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery. Polymers. 2018; 10(4):390. https://doi.org/10.3390/polym10040390

Chicago/Turabian Style

Khatoon, Shakera, Hwa S. Han, Jueun Jeon, N. V. Rao, Dae-Woong Jeong, M. Ikram, T. Yasin, Gi-Ra Yi, and Jae H. Park. 2018. "Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery" Polymers 10, no. 4: 390. https://doi.org/10.3390/polym10040390

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