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Polymers 2018, 10(3), 272;

ECM Decorated Electrospun Nanofiber for Improving Bone Tissue Regeneration

1,*, 2, 2 and 2,3,*
Department of ENT and Head & Neck Surgery, The Children’s Hospital Zhejiang University School of Medicine, 3333 Bingsheng Road, Hangzhou 310051, China
Orthopedic Institute, Soochow University, 708 Remin Road, Suzhou 215006, China
Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Authors to whom correspondence should be addressed.
Received: 25 January 2018 / Revised: 23 February 2018 / Accepted: 26 February 2018 / Published: 6 March 2018
(This article belongs to the Special Issue Polymer Scaffolds for Biomedical Application)
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Optimization of nanofiber surface properties can lead to enhanced tissue regeneration outcomes in the context of bone tissue engineering. Herein, we developed a facile strategy to decorate elctrospun nanofibers using extracellular matrix (ECM) in order to improve their performance for bone tissue engineering. Electrospun PLLA nanofibers (PLLA NF) were seeded with MC3T3-E1 cells and allowed to grow for two weeks in order to harvest a layer of ECM on nanofiber surface. After decellularization, we found that ECM was successfully preserved on nanofiber surface while maintaining the nanostructure of electrospun fibers. ECM decorated on PLLA NF is biologically active, as evidenced by its ability to enhance mouse bone marrow stromal cells (mBMSCs) adhesion, support cell proliferation and promote early stage osteogenic differentiation of mBMSCs. Compared to PLLA NF without ECM, mBMSCs grown on ECM/PLLA NF exhibited a healthier morphology, faster proliferation profile, and more robust osteogenic differentiation. Therefore, our study suggests that ECM decoration on electrospun nanofibers could serve as an efficient approach to improving their performance for bone tissue engineering. View Full-Text
Keywords: elctrospun nanofibers; extracellular matrix; biologically active; osteogenic differentiation; scaffolds elctrospun nanofibers; extracellular matrix; biologically active; osteogenic differentiation; scaffolds

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fu, Y.; Liu, L.; Cheng, R.; Cui, W. ECM Decorated Electrospun Nanofiber for Improving Bone Tissue Regeneration. Polymers 2018, 10, 272.

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