Next Article in Journal
In-Situ Incorporation of Alkyl-Grafted Silica into Waterborne Polyurethane with High Solid Content for Enhanced Physical Properties of Coatings
Next Article in Special Issue
Gelatin/Nanohyroxyapatite Cryogel Embedded Poly(lactic-co-glycolic Acid)/Nanohydroxyapatite Microsphere Hybrid Scaffolds for Simultaneous Bone Regeneration and Load-Bearing
Previous Article in Journal
Study of theThermo-/pH-Sensitivity of Stereo-Controlled Poly(N-isopropylacrylamide-co-IAM) Copolymers via RAFT Polymerization
Previous Article in Special Issue
ECM Decorated Electrospun Nanofiber for Improving Bone Tissue Regeneration
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Polymers 2018, 10(5), 513;

Phospholipid-Coated Mesoporous Silica Nanoparticles Acting as Lubricating Drug Nanocarriers

State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
Author to whom correspondence should be addressed.
Received: 7 April 2018 / Revised: 29 April 2018 / Accepted: 30 April 2018 / Published: 9 May 2018
(This article belongs to the Special Issue Polymer Scaffolds for Biomedical Application)
Full-Text   |   PDF [8400 KB, uploaded 9 May 2018]   |  


Osteoarthritis (OA) is a severe disease caused by wear and inflammation of joints. In this study, phospholipid-coated mesoporous silica nanoparticles ([email protected]) were prepared in order to treat OA at an early stage. The phospholipid layer has excellent lubrication capability in aqueous media due to the hydration lubrication mechanism, while mesoporous silica nanoparticles (MSNs) act as effective drug nanocarriers. The [email protected] were characterized by scanning electron microscope, transmission electron microscope, Fourier transform infrared spectrum, X-ray photoelectron spectrum, thermogravimetric analysis and dynamic light scattering techniques to confirm that the phospholipid layer was coated onto the surface of MSNs successfully. A series of tribological tests were performed under different experimental conditions, and the results showed that [email protected] with multi-layers of phospholipids greatly reduced the friction coefficient in comparison with MSNs. Additionally, [email protected] demonstrated sustained drug release behavior and were biocompatible based on CCK-8 assay using MC3T3-E1 cells. The [email protected] developed in the present study, acting as effective lubricating drug nanocarriers, may represent a promising strategy to treat early stage OA by lubrication enhancement and drug delivery therapy. View Full-Text
Keywords: osteoarthritis; mesoporous silica nanoparticles; phospholipids; hydration lubrication; drug delivery osteoarthritis; mesoporous silica nanoparticles; phospholipids; hydration lubrication; drug delivery

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Sun, T.; Sun, Y.; Zhang, H. Phospholipid-Coated Mesoporous Silica Nanoparticles Acting as Lubricating Drug Nanocarriers. Polymers 2018, 10, 513.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top