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Polymers 2018, 10(12), 1336; https://doi.org/10.3390/polym10121336

Polyelectrolyte-Coated Gold Nanoparticles: The Effect of Salt and Polyelectrolyte Concentration on Colloidal Stability

Flinders Institute for Nanoscale Science and Technology, College for Science and Engineering, Flinders University, Bedford Park 5042, South Australia
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Received: 8 November 2018 / Revised: 29 November 2018 / Accepted: 29 November 2018 / Published: 3 December 2018
(This article belongs to the Special Issue Nanotechnology of Polymers and Biomaterials)
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Abstract

Gold nanoparticles are widely used in biomedical applications. Their ease of surface modification, biocompatibility and the presence of surface plasmons makes them ideal tools for a variety of investigations. Polyelectrolyte-coated gold nanoparticles are employed in areas such as imaging, drug delivery and gene therapy; however, it is not well understood how different factors such as the polyelectrolyte and salt concentration affect the coating on the nanoparticles and hence their performance. Here, these parameters were systematically varied and their effect on the stability of the colloidal nanoparticle suspension was monitored. An increase in the polyelectrolyte concentration from 0 to 30 mg/mL led to a red shift of the surface plasmon peak and an increase in the zeta potential. Concentrations between 5 mg/mL and 30 mg/mL resulted in the most stable systems, with 1 mg/mL being the most unstable. Stable nanoparticle suspensions were formed in salt concentrations below 50 mM, while higher concentrations caused colloidal instability and irreversible aggregation. View Full-Text
Keywords: polyelectrolyte; stability; gold nanoparticles; gold; biomedical polyelectrolyte; stability; gold nanoparticles; gold; biomedical
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fuller, M.; Kӧper, I. Polyelectrolyte-Coated Gold Nanoparticles: The Effect of Salt and Polyelectrolyte Concentration on Colloidal Stability. Polymers 2018, 10, 1336.

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