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Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors
 
 
Article
Peer-Review Record

Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors

Catalysts 2019, 9(4), 308; https://doi.org/10.3390/catal9040308
by Osamu Tonomura 1,*, Satoshi Taniguchi 1, Kazuki Nishi 1, Aiichiro Nagaki 2,*, Jun-ichi Yoshida 2, Katsuyuki Hirose 2, Norio Ishizuka 3 and Shinji Hasebe 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Catalysts 2019, 9(4), 308; https://doi.org/10.3390/catal9040308
Submission received: 15 March 2019 / Accepted: 25 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Catalysts for Suzuki–Miyaura Coupling Reaction)

Round 1

Reviewer 1 Report

This is an interesting piece of work, with much potential to contribute to rationally designed control elements in parallel flow reactors. This is a fundamental endeavour when long-term, unattended operation of flow systems is envisaged. I recommend publication of this manuscript in  Catalysts

Reviewer 2 Report

Tonomura and co-workers reports an original work related to the use of a blockage detection and diagnosis method for parallelized monolithic microreactors involved in a Suzuki-Miyaura cross-coupling reaction. The work was conducted with care and the manuscript is well written. The results provided in this contribution should be of high interest for chemical engineers and synthetic chemists working with microreactors. For all these reasons, I recommend this manuscript for publication in Catalysts without alteration.


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