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Catalysts 2019, 9(4), 308; https://doi.org/10.3390/catal9040308

Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors

1
Department of Chemical Engineering, Kyoto University, Nishikyo, Kyoto 615-8510, Japan
2
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Nishikyo, Kyoto 615-8510, Japan
3
Emaus Kyoto Inc. R&D, 26 Nishida-cho, Saiin, Ukyo, Kyoto 615-0055, Japan
*
Authors to whom correspondence should be addressed.
Received: 15 March 2019 / Accepted: 25 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Catalysts for Suzuki–Miyaura Coupling Reaction)
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Abstract

To realize stable operation of a microchemical system, it is necessary to develop a process monitoring method that can detect and diagnose blocked microreactors. In this study, a system composed of five monolithic microreactors and a split-and-recombine-type flow distributor (SRFD) was developed for Suzuki–Miyaura coupling. Firstly, the effects of operating conditions on the yield was examined by using a single microreactor. After that, an optimal design problem was formulated to maximize the blockage detection performance by adjusting the channel resistances of the SRFD and the sensor locations in the SRFD under the design constraints. To efficiently solve the problem, a pressure drop compartment model, which is analogous to electrical resistance networks, was used. The optimally designed system was experimentally evaluated from the viewpoint of the capability of continuous operation and the blockage detection and diagnosis performance. The evaluation results show that continuous operation was successfully carried out for one hour, and that the artificially generated blockage of each microreactor was accurately identified. The developed system minimized the process performance degradation due to blockage. View Full-Text
Keywords: monolithic microreactor; numbering-up; process monitoring; blockage; flow distributor design; Suzuki–Miyaura coupling monolithic microreactor; numbering-up; process monitoring; blockage; flow distributor design; Suzuki–Miyaura coupling
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Tonomura, O.; Taniguchi, S.; Nishi, K.; Nagaki, A.; Yoshida, J.-I.; Hirose, K.; Ishizuka, N.; Hasebe, S. Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors. Catalysts 2019, 9, 308.

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