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Catalysts 2019, 9(4), 305; https://doi.org/10.3390/catal9040305

A Photo-Enzymatic Cascade to Transform Racemic Alcohols into Enantiomerically Pure Amines

1
Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629HZ Delft, The Netherlands
2
Van’t Hoff Institute for Molecular Sciences (HIMS-Biocat), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 27 February 2019 / Revised: 17 March 2019 / Accepted: 20 March 2019 / Published: 27 March 2019
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Abstract

The consecutive photooxidation and reductive amination of various alcohols in a cascade reaction were realized by the combination of a photocatalyst and several enzymes. Whereas the photocatalyst (sodium anthraquinone-2-sulfonate) mediated the light-driven, aerobic oxidation of primary and secondary alcohols, the enzymes (various ω-transaminases) catalyzed the enantio-specific reductive amination of the intermediate aldehydes and ketones. The system worked in a one-pot one-step fashion, whereas the productivity was significantly improved by switching to a one-pot two-step procedure. A wide range of aliphatic and aromatic compounds was transformed into the enantiomerically pure corresponding amines via the photo-enzymatic cascade. View Full-Text
Keywords: photooxidation; cascade; alcohol; reductive amination; ω-transaminase photooxidation; cascade; alcohol; reductive amination; ω-transaminase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Gacs, J.; Zhang, W.; Knaus, T.; Mutti, F.G.; Arends, I.W.; Hollmann, F. A Photo-Enzymatic Cascade to Transform Racemic Alcohols into Enantiomerically Pure Amines. Catalysts 2019, 9, 305.

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