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Catalysts 2019, 9(3), 272; https://doi.org/10.3390/catal9030272

Microwave-Assisted Homogeneous Acid Catalysis and Chemoenzymatic Synthesis of Dialkyl Succinate in a Flow Reactor

1
Centre de Recherche de Royallieu, Université de Technologie Compiègne, Sorbonne Universités, Cedex BP20529, F-60205 Compiègne, France
2
School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, China
3
Institut de Recherche de Chimie Paris, PSL Research University, Chimie ParisTech, CNRS, UMR 8247, Cedex 05, F-75231 Paris, France
*
Author to whom correspondence should be addressed.
Received: 12 February 2019 / Revised: 7 March 2019 / Accepted: 8 March 2019 / Published: 16 March 2019
(This article belongs to the Special Issue Catalytic Methods in Flow Chemistry)
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Abstract

Two new continuous flow systems for the production of dialkyl succinates were developed via the esterification of succinic acid, and via the trans-esterification of dimethyl succinate. The first microwave-assisted continuous esterification of succinic acid with H2SO4 as a chemical homogeneous catalyst was successfully achieved via a single pass (ca 320 s) at 65–115 °C using a MiniFlow 200ss Sairem Technology. The first continuous trans-esterification of dimethyl succinate with lipase Cal B as an enzymatic catalyst was developed using a Syrris Asia Technology, with an optimal reaction condition of 14 min at 40 °C. Dialkyl succinates were produced with the two technologies, but higher productivity was observed for the microwave-assisted continuous esterification using chemical catalysts. The continuous flow trans-esterification demonstrated a number of advantages, but it resulted in lower yield of the target esters. View Full-Text
Keywords: continuous flow; dialkyl succinates; homogeneous catalysis; lipase Cal B; succinate continuous flow; dialkyl succinates; homogeneous catalysis; lipase Cal B; succinate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Daviot, L.; Len, T.; Lin, C.S.K.; Len, C. Microwave-Assisted Homogeneous Acid Catalysis and Chemoenzymatic Synthesis of Dialkyl Succinate in a Flow Reactor. Catalysts 2019, 9, 272.

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