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Catalysts 2019, 9(3), 221; https://doi.org/10.3390/catal9030221

Industrial Application of 2-Oxoglutarate-Dependent Oxygenases

Competence Center for Biocatalysis, Institute of Chemistry and Biotechnology, Department of Life Sciences and Facility Management, Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820 Waedenswil, Switzerland
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Received: 11 February 2019 / Revised: 22 February 2019 / Accepted: 25 February 2019 / Published: 28 February 2019
(This article belongs to the Special Issue Biocatalysis for Industrial Applications)
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Abstract

C–H functionalization is a chemically challenging but highly desirable transformation. 2-oxoglutarate-dependent oxygenases (2OGXs) are remarkably versatile biocatalysts for the activation of C–H bonds. In nature, they have been shown to accept both small and large molecules carrying out a plethora of reactions, including hydroxylations, demethylations, ring formations, rearrangements, desaturations, and halogenations, making them promising candidates for industrial manufacture. In this review, we describe the current status of 2OGX use in biocatalytic applications concentrating on 2OGX-catalyzed oxyfunctionalization of amino acids and synthesis of antibiotics. Looking forward, continued bioinformatic sourcing will help identify additional, practical useful members of this intriguing enzyme family, while enzyme engineering will pave the way to enhance 2OGX reactivity for non-native substrates. View Full-Text
Keywords: 2-oxoglutarate-dependent oxygenases; industrial biocatalysis; hydroxylation; alpha-ketoglutarate; amino acid modification; antibiotic synthesis 2-oxoglutarate-dependent oxygenases; industrial biocatalysis; hydroxylation; alpha-ketoglutarate; amino acid modification; antibiotic synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Peters, C.; Buller, R.M. Industrial Application of 2-Oxoglutarate-Dependent Oxygenases. Catalysts 2019, 9, 221.

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