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Open AccessReview

The Combination of Lewis Acid with N-Heterocyclic Carbene (NHC) Catalysis

1
Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing 408100, China
2
College of Pharmaceutical Science, Southwest University, Chongqing 400715, China
*
Author to whom correspondence should be addressed.
Catalysts 2019, 9(10), 863; https://doi.org/10.3390/catal9100863
Received: 16 September 2019 / Revised: 5 October 2019 / Accepted: 14 October 2019 / Published: 16 October 2019
(This article belongs to the Special Issue New Trends in Asymmetric Catalysis)
In the last ten years, the combination of Lewis acid with N-heterocyclic carbene (NHC) catalysis has emerged as a powerful strategy in a variety of important asymmetric synthesis, due to the ready availability of starting materials, operational simplicity and mild reaction conditions. Recent findings illustrate that Lewis acid could largely enhance the efficiency and enantioselectivity, reverse the diastereoselectivity, and even influence the pathway of the same reaction partners. Herein, this review aims to reveal the recent advances in NHC-Lewis acid synergistically promoted enantioselective reactions for the expeditious assembly of versatile biologically important chiral pharmaceuticals and natural products. View Full-Text
Keywords: N-heterocyclic carbenes (NHC); Lewis acid; cooperative catalysis; asymmetric synthesis; umpolung N-heterocyclic carbenes (NHC); Lewis acid; cooperative catalysis; asymmetric synthesis; umpolung
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MDPI and ACS Style

Jia, Q.; Li, Y.; Lin, Y.; Ren, Q. The Combination of Lewis Acid with N-Heterocyclic Carbene (NHC) Catalysis. Catalysts 2019, 9, 863.

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