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Open AccessArticle

Selective Reduction of Ketones and Aldehydes in Continuous-Flow Microreactor—Kinetic Studies

1
Institute of Chemical Engineering Polish Academy of Sciences, Bałtycka 5, 44-100 Gliwice, Poland
2
Department of Chemical Engineering and Process Design, Silesian University of Technology, Ks. M. Strzody 7, 44-100 Gliwice, Poland
*
Author to whom correspondence should be addressed.
Catalysts 2018, 8(5), 221; https://doi.org/10.3390/catal8050221
Received: 24 April 2018 / Revised: 14 May 2018 / Accepted: 18 May 2018 / Published: 22 May 2018
(This article belongs to the Special Issue Catalytic Methods in Flow Chemistry)
In this work, the kinetics of Meerwein–Ponndorf–Verley chemoselective reduction of carbonyl compounds was studied in monolithic continuous-flow microreactors. To the best of our knowledge, this is the first report on the MPV reaction kinetics performed in a flow process. The microreactors are a very attractive alternative to the batch reactors conventionally used in this process. The proposed micro-flow system for synthesis of unsaturated secondary alcohols proved to be very efficient and easily controlled. The microreactors had reactive cores made of zirconium-functionalized silica monoliths of excellent catalytic properties and flow characteristics. The catalytic experiments were carried out with the use of 2-butanol as a hydrogen donor. Herein, we present the kinetic parameters of cyclohexanone reduction in a flow reactor and data on the reaction rate for several important ketones and aldehydes. The lack of diffusion constraints in the microreactors was demonstrated. Our results were compared with those from other authors and demonstrate the great potential of microreactor applications in fine chemical and complex intermediate manufacturing. View Full-Text
Keywords: Meerwein–Ponndorf–Verley reduction; kinetics; flow microreactor Meerwein–Ponndorf–Verley reduction; kinetics; flow microreactor
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MDPI and ACS Style

Maresz, K.; Ciemięga, A.; Mrowiec-Białoń, J. Selective Reduction of Ketones and Aldehydes in Continuous-Flow Microreactor—Kinetic Studies. Catalysts 2018, 8, 221.

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