From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose
AbstractNotably available from the cellulose contained in lignocellulosic biomass, glucose is a highly attractive substrate for eco-efficient processes towards high-value chemicals. A recent strategy for biomass valorization consists on combining biocatalysis and chemocatalysis to realise the so-called chemo-enzymatic or hybrid catalysis. Optimisation of the glucose conversion to 5-hydroxymethylfurfural (HMF) is the object of many research efforts. HMF can be produced by chemo-catalyzed fructose dehydration, while fructose can be selectively obtained from enzymatic glucose isomerization. Despite recent advances in HMF production, a fully integrated efficient process remains to be demonstrated. Our innovative approach consists on a continuous process involving enzymatic glucose isomerization, selective arylboronic-acid mediated fructose complexation/transportation, and chemical fructose dehydration to HMF. We designed a novel reactor based on two aqueous phases dynamically connected via an organic liquid membrane, which enabled substantial enhancement of glucose conversion (70%) while avoiding intermediate separation steps. Furthermore, in the as-combined steps, the use of an immobilized glucose isomerase and an acidic resin facilitates catalyst recycling. View Full-Text
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Gimbernat, A.; Guehl, M.; Lopes Ferreira, N.; Heuson, E.; Dhulster, P.; Capron, M.; Dumeignil, F.; Delcroix, D.; Girardon, J.-S.; Froidevaux, R. From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose. Catalysts 2018, 8, 335.
Gimbernat A, Guehl M, Lopes Ferreira N, Heuson E, Dhulster P, Capron M, Dumeignil F, Delcroix D, Girardon J-S, Froidevaux R. From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose. Catalysts. 2018; 8(8):335.Chicago/Turabian Style
Gimbernat, Alexandra; Guehl, Marie; Lopes Ferreira, Nicolas; Heuson, Egon; Dhulster, Pascal; Capron, Mickael; Dumeignil, Franck; Delcroix, Damien; Girardon, Jean-Sébastien; Froidevaux, Rénato. 2018. "From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose." Catalysts 8, no. 8: 335.
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