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Open AccessArticle

From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose

Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d’Opale, EA7394–ICV-Institut Charles Viollette, F-59000 Lille, France
Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F-59000 Lille, France
IFP Energies Nouvelles, Rond-point de l’échangeur de Solaize, BP 3, 69360 Solaize, France
IFP Energies Nouvelles, 1 et 4 avenue de Bois-Préau, 92852 Rueil Malmaison, France
Author to whom correspondence should be addressed.
Catalysts 2018, 8(8), 335;
Received: 13 July 2018 / Revised: 23 July 2018 / Accepted: 27 July 2018 / Published: 17 August 2018
(This article belongs to the Special Issue Catalytic Methods in Flow Chemistry)
Notably available from the cellulose contained in lignocellulosic biomass, glucose is a highly attractive substrate for eco-efficient processes towards high-value chemicals. A recent strategy for biomass valorization consists on combining biocatalysis and chemocatalysis to realise the so-called chemo-enzymatic or hybrid catalysis. Optimisation of the glucose conversion to 5-hydroxymethylfurfural (HMF) is the object of many research efforts. HMF can be produced by chemo-catalyzed fructose dehydration, while fructose can be selectively obtained from enzymatic glucose isomerization. Despite recent advances in HMF production, a fully integrated efficient process remains to be demonstrated. Our innovative approach consists on a continuous process involving enzymatic glucose isomerization, selective arylboronic-acid mediated fructose complexation/transportation, and chemical fructose dehydration to HMF. We designed a novel reactor based on two aqueous phases dynamically connected via an organic liquid membrane, which enabled substantial enhancement of glucose conversion (70%) while avoiding intermediate separation steps. Furthermore, in the as-combined steps, the use of an immobilized glucose isomerase and an acidic resin facilitates catalyst recycling. View Full-Text
Keywords: (bio) catalysis; biomass; glucose; 5-hydroxymethylfurfural (HMF); chemo-enzymatic catalysis (bio) catalysis; biomass; glucose; 5-hydroxymethylfurfural (HMF); chemo-enzymatic catalysis
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Gimbernat, A.; Guehl, M.; Lopes Ferreira, N.; Heuson, E.; Dhulster, P.; Capron, M.; Dumeignil, F.; Delcroix, D.; Girardon, J.-S.; Froidevaux, R. From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose. Catalysts 2018, 8, 335.

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