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Catalysts 2018, 8(5), 205; https://doi.org/10.3390/catal8050205

Artificial Biocatalytic Linear Cascades to Access Hydroxy Acids, Lactones, and α- and β-Amino Acids

1
Institute of Chemistry, Organic and Bioorganic Chemistry, University of Graz, NAWI Graz, BioTechMed Graz, Heinrichstrasse 28, 8010 Graz, Austria
2
ACIB GmbH, c/o Department of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Received: 25 April 2018 / Revised: 7 May 2018 / Accepted: 8 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Enzymatic Cascade Reactions)
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Abstract

α-, β-, and ω-Hydroxy acids, amino acids, and lactones represent common building blocks and intermediates for various target molecules. This review summarizes artificial cascades published during the last 10 years leading to these products. Renewables as well as compounds originating from fossil resources have been employed as starting material. The review provides an inspiration for new cascade designs and may be the basis to design variations of these cascades starting either from alternative substrates or extending them to even more sophisticated products. View Full-Text
Keywords: cascade; biocatalysis; biotransformations; hydroxy acids; lactones and α- and β-amino acids cascade; biocatalysis; biotransformations; hydroxy acids; lactones and α- and β-amino acids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Schrittwieser, J.H.; Velikogne, S.; Kroutil, W. Artificial Biocatalytic Linear Cascades to Access Hydroxy Acids, Lactones, and α- and β-Amino Acids. Catalysts 2018, 8, 205.

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