Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation

Boratyński, Filip; Szczepańska, Ewa; Grudniewska, Aleksandra; Olejniczak, Teresa

doi:10.3390/catal8010028

Open AccessArticle

Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation

by

Filip Boratyński

^*

,

Ewa Szczepańska

,

Aleksandra Grudniewska

and

Teresa Olejniczak

Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland

^*

Author to whom correspondence should be addressed.

Catalysts 2018, 8(1), 28; https://doi.org/10.3390/catal8010028

Submission received: 14 December 2017 / Revised: 12 January 2018 / Accepted: 13 January 2018 / Published: 16 January 2018

(This article belongs to the Special Issue Enzyme-Mediated Stereoselective Synthesis)

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Abstract

A novel microbial approach to the production of enantiomerically enriched and pure aroma compounds based on kinetic resolution via solid-state fermentation is proposed. Twenty-five filamentous fungi were screened for lipase activity and enantioselective hydrolysis of a volatile racemic ester (1-phenylethyl acetate (1)) and several racemic lactones (trans and cis whisky lactones (4, 5), γ-decalactone (7), δ-decalactone (8), (cis-3a,4,7,7a-tetrahydro-1(3H)-isobenzofuranone) (9)). Solid-state fermentation was conducted with linseed and rapeseed cakes. Kinetic resolution afforded enantiomerically enriched products with high enantiomeric excesses (ee = 82–99%). The results highlight the potential economic value of solid-state fermentation using agroindustrial side-stream feedstocks as an alternative to more expensive processes conducted in submerged fermentation.

Keywords: aroma compounds; kinetic resolution; solid-state fermentation; agro-industrial side stream; rapeseed cake; linseed cake; lactones; esters

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MDPI and ACS Style

Boratyński, F.; Szczepańska, E.; Grudniewska, A.; Olejniczak, T. Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation. Catalysts 2018, 8, 28. https://doi.org/10.3390/catal8010028

AMA Style

Boratyński F, Szczepańska E, Grudniewska A, Olejniczak T. Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation. Catalysts. 2018; 8(1):28. https://doi.org/10.3390/catal8010028

Chicago/Turabian Style

Boratyński, Filip, Ewa Szczepańska, Aleksandra Grudniewska, and Teresa Olejniczak. 2018. "Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation" Catalysts 8, no. 1: 28. https://doi.org/10.3390/catal8010028

APA Style

Boratyński, F., Szczepańska, E., Grudniewska, A., & Olejniczak, T. (2018). Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation. Catalysts, 8(1), 28. https://doi.org/10.3390/catal8010028

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation

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