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Microwave-Assisted Regioselective Suzuki Coupling of 2,4-Dichloropyrimidines with Aryl and Heteroaryl Boronic Acids

Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia
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Academic Editor: Armando Carlone
Catalysts 2021, 11(4), 439; https://doi.org/10.3390/catal11040439
Received: 5 March 2021 / Revised: 24 March 2021 / Accepted: 26 March 2021 / Published: 30 March 2021
(This article belongs to the Special Issue Advances in Transition Metal Catalyzed Cross-Coupling)
Suzuki coupling reaction has been often used for the preparation of a diverse set of substituted pyrimidines. In this study, the Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough screening of reaction conditions and the use of microwave irradiation led to a very efficient and straightforward synthetic procedure providing C4-substituted pyrimidines in good to excellent yields. Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) are the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of substituted pyrimidine rings. View Full-Text
Keywords: cross-coupling; Suzuki; palladium; pyrimidines; synthesis; microwave-assisted cross-coupling; Suzuki; palladium; pyrimidines; synthesis; microwave-assisted
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MDPI and ACS Style

Dolšak, A.; Mrgole, K.; Sova, M. Microwave-Assisted Regioselective Suzuki Coupling of 2,4-Dichloropyrimidines with Aryl and Heteroaryl Boronic Acids. Catalysts 2021, 11, 439. https://doi.org/10.3390/catal11040439

AMA Style

Dolšak A, Mrgole K, Sova M. Microwave-Assisted Regioselective Suzuki Coupling of 2,4-Dichloropyrimidines with Aryl and Heteroaryl Boronic Acids. Catalysts. 2021; 11(4):439. https://doi.org/10.3390/catal11040439

Chicago/Turabian Style

Dolšak, Ana; Mrgole, Kristjan; Sova, Matej. 2021. "Microwave-Assisted Regioselective Suzuki Coupling of 2,4-Dichloropyrimidines with Aryl and Heteroaryl Boronic Acids" Catalysts 11, no. 4: 439. https://doi.org/10.3390/catal11040439

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