Next Article in Journal
Cimetidine and Clobenpropit Attenuate Inflammation-Associated Colorectal Carcinogenesis in Male ICR Mice
Previous Article in Journal
Association between Genetic Variants in DNA Double-Strand Break Repair Pathways and Risk of Radiation Therapy-Induced Pneumonitis and Esophagitis in Non-Small Cell Lung Cancer
Open AccessReview

The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis

Department of Otolaryngology—Head and Neck Surgery, University of Southern California, 1450 San Pablo St, Suite 5100, Los Angeles, CA 90033, USA
*
Author to whom correspondence should be addressed.
Academic Editor: David Wong
Cancers 2016, 8(2), 24; https://doi.org/10.3390/cancers8020024
Received: 7 September 2015 / Revised: 7 February 2016 / Accepted: 16 February 2016 / Published: 19 February 2016
The cancer stem cell (CSC) theory proposes that a minority of tumor cells are capable of self-replication and tumorigenesis. It is these minority of cells that are responsible for cancer metastasis and recurrence in head and neck squamous cell cancers (HNSCC). Human papilloma virus (HPV)-related cancer of the oropharynx is becoming more prevalent, which makes understanding of the relationship between HPV and CSCs more important than ever. This relationship is critical because CSC behavior can be predicted based on cell surface markers, which makes them a suitable candidate for targeted therapy. New therapies are an exciting opportunity to advance past the stalled outcomes in HNSCC that have plagued patients and clinicians for several decades. View Full-Text
Keywords: cancer stem cell; cancer initiating cell; human papilloma virus; HPV; Notch; Oct-4; Nanog cancer stem cell; cancer initiating cell; human papilloma virus; HPV; Notch; Oct-4; Nanog
MDPI and ACS Style

Swanson, M.S.; Kokot, N.; Sinha, U.K. The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis. Cancers 2016, 8, 24.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop