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Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells?

Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Alba Minelli
Cancers 2016, 8(10), 92; https://doi.org/10.3390/cancers8100092
Received: 5 September 2016 / Revised: 30 September 2016 / Accepted: 7 October 2016 / Published: 13 October 2016
(This article belongs to the Special Issue Antioxidants in Cancer)
Antioxidant defenses encompass a variety of distinct compounds and enzymes that are linked together through their capacity to neutralize and scavenge reactive oxygen species (ROS). While the relationship between ROS and tumorigenesis is clearly complex and context dependent, a number of recent studies have suggested that neutralizing ROS can facilitate tumor progression and metastasis in multiple cancer types through distinct mechanisms. These studies therefore infer that antioxidant activity may be necessary to support the viability and/or the invasive capacity of cancer cells during tumor progression and metastasis. Here, we discuss some of the accumulating evidence suggesting a role for antioxidant activity in facilitating tumor progression. View Full-Text
Keywords: antioxidant; reactive oxygen species; extracellular matrix; NADPH; Nrf2; pentose phosphate pathway; metastasis antioxidant; reactive oxygen species; extracellular matrix; NADPH; Nrf2; pentose phosphate pathway; metastasis
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Hawk, M.A.; McCallister, C.; Schafer, Z.T. Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells? Cancers 2016, 8, 92.

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