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Cancers 2010, 2(3), 1565-1575;

Stereotactic Body Radiation Therapy (SBRT) for Unresectable Pancreatic Carcinoma

Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA
Author to whom correspondence should be addressed.
Received: 28 July 2010 / Revised: 5 August 2010 / Accepted: 6 August 2010 / Published: 9 August 2010
(This article belongs to the Special Issue Pancreatic Cancer)
Full-Text   |   PDF [138 KB, uploaded 9 August 2010]


Survival in patients with unresectable pancreatic carcinoma is poor. Studies by Mayo Clinic and the Gastrointestinal Tumor Study Group (GITSG) have established combined modality treatment with chemotherapy and radiation as the standard of care. Use of gemcitabine-based chemotherapy alone has also been shown to provide a benefit, but 5‑year overall survival still remains less than 5%. Conventional radiotherapy is traditionally delivered over a six week period and high toxicity is seen with the concomitant use of chemotherapy. In contrast, SBRT can be delivered in 3–5 days and, when used as a component of combined modality therapy with gemcitabine, disruption to the timely delivery of chemotherapy is minimal. Early single-institution reports of SBRT for unresectable pancreatic carcinoma demonstrate excellent local control with acceptable toxicity. Use of SBRT in unresectable pancreatic carcinoma warrants further investigation in order to improve the survival of patients with historically poor outcomes. View Full-Text
Keywords: stereotactic radiotherapy; radiotherapy; pancreatic neoplasms stereotactic radiotherapy; radiotherapy; pancreatic neoplasms
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Stauder, M.C.; Miller, R.C. Stereotactic Body Radiation Therapy (SBRT) for Unresectable Pancreatic Carcinoma. Cancers 2010, 2, 1565-1575.

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