Next Article in Journal
A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
Next Article in Special Issue
Stereotactic Body Radiation Therapy (SBRT) for Unresectable Pancreatic Carcinoma
Previous Article in Journal / Special Issue
The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer
Open AccessReview

Neural Invasion in Pancreatic Cancer: The Past, Present and Future

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
*
Author to whom correspondence should be addressed.
Cancers 2010, 2(3), 1513-1527; https://doi.org/10.3390/cancers2031513
Received: 2 June 2010 / Revised: 30 June 2010 / Accepted: 7 July 2010 / Published: 14 July 2010
(This article belongs to the Special Issue Pancreatic Cancer)
In the past 15 years, invasion of nerves by cancer cells has escaped from its role as a mere bystander in cancer biology and turned into an attractive niche to study the heterotypic interaction between cancer cells and neurons. Today, neural invasion (NI) in pancreatic cancer (PCa) stands out due to the recent demonstration of its association with tumor progression, local recurrence and neuropathic pain. Accordingly, recent research on NI in PCa revealed the critical involvement of numerous nerve- or cancer cell-derived molecules in several novel in vitro and in vivo models of NI, which, however, still need further major improvement. View Full-Text
Keywords: neural invasion; neurotrophic factors; pancreatic neuropathy; neuroplasticity; neurotropism neural invasion; neurotrophic factors; pancreatic neuropathy; neuroplasticity; neurotropism
Show Figures

Graphical abstract

MDPI and ACS Style

Demir, I.E.; Ceyhan, G.O.; Liebl, F.; D’Haese, J.G.; Maak, M.; Friess, H. Neural Invasion in Pancreatic Cancer: The Past, Present and Future. Cancers 2010, 2, 1513-1527. https://doi.org/10.3390/cancers2031513

AMA Style

Demir IE, Ceyhan GO, Liebl F, D’Haese JG, Maak M, Friess H. Neural Invasion in Pancreatic Cancer: The Past, Present and Future. Cancers. 2010; 2(3):1513-1527. https://doi.org/10.3390/cancers2031513

Chicago/Turabian Style

Demir, Ihsan Ekin; Ceyhan, Güralp O.; Liebl, Florian; D’Haese, Jan G.; Maak, Matthias; Friess, Helmut. 2010. "Neural Invasion in Pancreatic Cancer: The Past, Present and Future" Cancers 2, no. 3: 1513-1527. https://doi.org/10.3390/cancers2031513

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop