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Cancers
Volume 18
Issue 6
10.3390/cancers18061045
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Article
Peer-Review Record

Lymph Node Assessment with Multiparametric Ultrasound: Normal Values, Morphologic Patterns, and Diagnostic Algorithms

Cancers 2026, 18(6), 1045; https://doi.org/10.3390/cancers18061045
by Kathleen Möller 1, Christian Jenssen 2,3, Markus Herbert Lerchbaumer 4, Alois Hollerweger 5, Madhvi Yadav 6, Manjiri Dighe 6, Carla Serra 7, Andrea Boccatonda 7, Siegbert Faiss 1 and Christoph Frank Dietrich 8,*
Reviewer 1: Anonymous
Reviewer 2:
Georgios Iatrakis
Cancers 2026, 18(6), 1045; https://doi.org/10.3390/cancers18061045
Submission received: 27 January 2026 / Revised: 3 March 2026 / Accepted: 17 March 2026 / Published: 23 March 2026
(This article belongs to the Special Issue Recent Advances in Endoscopic, Metabolomic, and Ultrasound Approaches to Gastrointestinal, Hepatic, and Pancreatic Tumors)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

General remarks

This is an in-depth review on the USG appearance of lymph node and its morphological abnormality. The authors have reviewed the area of USG in lymph node and provided many valuable findings. The article may be helpful to the radiologists.

Specific comments

  1. The article is more suited for a radiology journal.
  2. The introduction and materials are fine.
  3. What is the histopathology correlation of these studies? What is the senility and specificity of the radiological findings and diagnosis with the histopathology or cytology?
  4. How many average cases were there in each study?
  5. The figures are too many. The authors should reduce the number of figures.
  6. There is significant overlapping of the different radiological features.

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

-The main question addressed by the research is related to the benefits of the multiparametric ultrasound. 

-The topic is original addressing a specific gap in the field because it examines the spectrum of possible diagnostic applications of the method.

-Compared with other published material, it adds to the field that there are some specific advantages of the method related to the diagnostic confidence, and reducing the need for invasive procedures. 

-The specific improvements the authors should consider regarding the 

methodology are related to the fact that according to recent guidelines axillary ultrasound can replace sentinel node investigation in breast cancer. Considering that breast cancer is the most commonly diagnosed cancer in women worldwide, the application of the method for this purpose should be further commented. 

-The conclusions are consistent with the evidence and arguments presented and they address the main question posed because the conclusions are strictly related to the usefulness of multiparametric ultrasound in clinical and oncologic practice. 

-The references are appropriate. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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