Racial and Ethnic Disparities in Fertility Preservation for Women with Cancer in the United States—Identifying Systemic Barriers and Proposing Solutions Through the DART Hypothesis
Simple Summary
Abstract
1. Introduction
2. Methods
3. Fertility Preservation Overview
4. Current Racial and Ethnic Disparities in Fertility Preservation for Women with Cancer in the US
4.1. Fertility-Sparing Treatments
4.2. Counseling
4.3. Timely Referral
4.4. Access and Utilization of Fertility Preservation
5. Pathways for Accelerated Change—DART Hypothesis Revisited
6. Future Directions
7. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
- Miller, K.D.; Fidler-Benaoudia, M.; Keegan, T.H.; Hipp, H.S.; Jemal, A.; Siegel, R.L. Cancer statistics for adolescents and young adults, 2020. CA Cancer J. Clin. 2020, 70, 443–459. [Google Scholar] [CrossRef]
- Reynolds, A.C.; McKenzie, L.J. Cancer Treatment-Related Ovarian Dysfunction in Women of Childbearing Potential: Management and Fertility Preservation Options. J. Clin. Oncol. 2023, 41, 2281–2292. [Google Scholar] [CrossRef] [PubMed]
- Logan, S.; Perz, J.; Ussher, J.M.; Peate, M.; Anazodo, A. Systematic review of fertility-related psychological distress in cancer patients: Informing on an improved model of care. Psychooncology 2019, 28, 22–30. [Google Scholar] [CrossRef]
- Ethics Committee of the American Society for Reproductive Medicine. Fertility preservation and reproduction in patients facing gonadotoxic therapies: An Ethics Committee opinion. Fertil. Steril. 2018, 110, 380–386. [Google Scholar] [CrossRef] [PubMed]
- Su, H.I.; Lacchetti, C.; Letourneau, J.; Partridge, A.H.; Qamar, R.; Quinn, G.P.; Reinecke, J.; Smith, J.F.; Tesch, M.; Wallace, W.H.; et al. Fertility Preservation in People With Cancer: ASCO Guideline Update. J. Clin. Oncol. 2025, 43, 1488–1515. [Google Scholar] [CrossRef] [PubMed]
- ACOG Committee Opinion No. 747: Gynecologic Issues in Children and Adolescent Cancer Patients and Survivors. Obstet. Gynecol. 2018, 132, e67–e77. [CrossRef] [PubMed]
- Forman, E.J.; Anders, C.K.; Behera, M.A. A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients. Fertil. Steril. 2010, 94, 1652–1656. [Google Scholar] [CrossRef] [PubMed]
- Banerjee, R.; Tsiapali, E. Occurrence and recall rates of fertility discussions with young breast cancer patients. Support. Care Cancer 2016, 24, 163–171. [Google Scholar] [CrossRef]
- Turner, K.A.; Spurlin, E.E.; Jimenez, P.T. Disparities in Female Oncofertility Care in the United States: More Questions than Answers. Life 2023, 13, 1547. [Google Scholar] [CrossRef]
- Jorgensen, K.; Meernik, C.; Wu, C.F.; Murphy, C.C.; Baker, V.L.; Jarmon, P.; Brady, P.C.; Nitecki, R.; Nichols, H.B.; Rauh-Hain, J.A. Disparities in Fertility-Sparing Treatment and Use of Assisted Reproductive Technology After a Diagnosis of Cervical, Ovarian, or Endometrial Cancer. Obstet. Gynecol. 2023, 141, 341–353. [Google Scholar] [CrossRef] [PubMed]
- Kanbergs, A.; Jorgensen, K.; Agusti, N.; Viveros-Carreño, D.; Wu, C.-F.; Nitecki, R.; Harris, J.A.M.; Woodard, T.; Ramphul, R.; Rauh-Hain, J.A. Patient Location and Disparities in Access to Fertility Preservation for Women with Gynecologic or Breast Cancer. Obstet. Gynecol. 2024, 143, 824–834. [Google Scholar] [CrossRef]
- Gadson, A.K.; Sauerbrun-Cutler, M.T.; Eaton, J.L. Racial Disparities in Fertility Care: A Narrative Review of Challenges in the Utilization of Fertility Preservation and ART in Minority Populations. J. Clin. Med. 2024, 13, 1060. [Google Scholar] [CrossRef]
- Seifer, D.B.; Sharara, F.I.; Jain, T. Toward a Better Understanding of Racial Disparities in Utilization and Outcomes of IVF Treatment in the USA. In Ethnic Differences in Fertility and Assisted Reproduction; Sharara, F.I., Ed.; Springer: New York, NY, USA, 2013; pp. 239–244. [Google Scholar] [CrossRef]
- Seifer, D.B.; Sharara, F.I.; Jain, T. The Disparities in ART (DART) Hypothesis of Racial and Ethnic Disparities in Access and Outcomes of IVF Treatment in the USA. Reprod. Sci. 2022, 29, 2084–2088. [Google Scholar] [CrossRef] [PubMed]
- Mahabamunuge, J.; Seifer, D.B. Moving Toward Narrowing the United States Gap in Assisted Reproductive Technology (ART) Racial and Ethnic Disparities in the Next Decade. J. Clin. Med. 2024, 13, 2224. [Google Scholar] [CrossRef] [PubMed]
- Weterings, M.A.; Glanville, E.; Van Eekelen, R.; Farquhar, C. Interventions for fertility preservation in women with cancer undergoing chemotherapy. Cochrane Database Syst. Rev. 2025, 6, CD012891. [Google Scholar] [CrossRef]
- Oktay, K.; Harvey, B.E.; Partridge, A.H.; Quinn, G.P.; Reinecke, J.; Taylor, H.S.; Wallace, W.H.; Wang, E.T.; Loren, A.W. Fertility Preservation in Patients with Cancer: ASCO Clinical Practice Guideline Update. J. Clin. Oncol. 2018, 36, 1994–2001. [Google Scholar] [CrossRef]
- Han, E.; Seifer, D.B. Oocyte Cryopreservation for Medical and Planned Indications: A Practical Guide and Overview. J. Clin. Med. 2023, 12, 3542. [Google Scholar] [CrossRef] [PubMed]
- Li, Z.; Hou, Y.; Cheng, Y.; Xu, L.; Wang, J.; Tian, L. Effect of grafting site on reproductive outcomes following cryopreserved ovarian tissue transplantation: A meta-analysis and systematic review. Reprod. Biol. Endocrinol. 2025, 24, 6. [Google Scholar] [CrossRef] [PubMed]
- Takei, K.; Huang, H.; Sato, H.; Kashiwabara, S.; Samejima, K.; Matsunaga, S.; Takai, Y. A Study on the Timing of Resumption of Menstruation After Interruption/Termination of GnRH Agonist Therapy in Premenopausal Breast Cancer Patients. J. Adolesc. Young Adult Oncol. 2025. ahead of print. [Google Scholar] [CrossRef]
- Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. Mature oocyte cryopreservation: A guideline. Fertil. Steril. 2013, 99, 37–43. [Google Scholar] [CrossRef]
- Katler, Q.S.; Shandley, L.M.; Hipp, H.S.; Kawwass, J.F. National egg-freezing trends: Cycle and patient characteristics with a focus on race/ethnicity. Fertil. Steril. 2021, 116, 528–537. [Google Scholar] [CrossRef]
- Lee, M.B.; Siavoshi, M.; Kwan, L.; Kroener, L. Elective fertility preservation: A national database study on trends in oocyte cryopreservation and oocyte utilization over a 5- to 7-year follow-up period. Am. J. Obstet. Gynecol. 2025, 234, 432–439. [Google Scholar] [CrossRef]
- Erden, M.; Rehman, S.; Oh, C.; Schwartz, B.M.; Kho, R.M. Fertility-Sparing Treatments in Patient with Gynecologic Cancers. Obstet. Gynecol. 2025, 147, 186–197. [Google Scholar] [CrossRef] [PubMed]
- Zebrack, B. Information and service needs for young adult cancer survivors. Support. Care Cancer 2009, 17, 349–357. [Google Scholar] [CrossRef] [PubMed]
- Vadaparampil, S.T.; Christie, J.; Quinn, G.P.; Fleming, P.; Stowe, C.; Bower, B.; Pal, T. A pilot study to examine patient awareness and provider discussion of the impact of cancer treatment on fertility in a registry-based sample of African American women with breast cancer. Support. Care Cancer 2012, 20, 2559–2564. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Lawson, A.K.; McGuire, J.M.; Noncent, E.; Olivieri, J.F.; Smith, K.N.; Marsh, E.E. Disparities in Counseling Female Cancer Patients for Fertility Preservation. J. Womens Health 2017, 26, 886–891. [Google Scholar] [CrossRef]
- Goodman, L.R.; Balthazar, U.; Kim, J.; Mersereau, J.E. Trends of socioeconomic disparities in referral patterns for fertility preservation consultation. Hum. Reprod. 2012, 27, 2076–2081. [Google Scholar] [CrossRef]
- Quinn, G.P.; Vadaparampil, S.T.; Lee, J.H.; Jacobsen, P.B.; Bepler, G.; Lancaster, J.; Keefe, D.L.; Albrecht, T.L. Physician Referral for Fertility Preservation in Oncology Patients: A National Study of Practice Behaviors. J. Clin. Oncol. 2009, 27, 5952–5957. [Google Scholar] [CrossRef] [PubMed]
- Chey, P.N.; Delwalla, M.L.M.; Shuford, J.; Albright, N.; Goebel, K.; Grigorian, J.; Rajagopalan, S.; Schirmer, D.A.; Hipp, H.S. Predictors of referral for fertility preservation counseling in patients diagnosed with cancer. J. Assist. Reprod. Genet. 2026. ahead of print. [Google Scholar] [CrossRef] [PubMed]
- Letourneau, J.M.; Smith, J.F.; Ebbel, E.E.; Craig, A.; Katz, P.P.; Cedars, M.I.; Rosen, M.P. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer: Fertility Preservation Disparities. Cancer 2012, 118, 4579–4588. [Google Scholar] [CrossRef] [PubMed]
- Voigt, P.; Persily, J.; Blakemore, J.K.; Licciardi, F.; Thakker, S.; Najari, B. Sociodemographic differences in utilization of fertility services among reproductive age women diagnosed with cancer in the USA. J. Assist. Reprod. Genet. 2022, 39, 963–972. [Google Scholar] [CrossRef] [PubMed]
- Lee, S.; Heytens, E.; Moy, F.; Ozkavukcu, S.; Oktay, K. Determinants of access to fertility preservation in women with breast cancer. Fertil. Steril. 2011, 95, 1932–1936. [Google Scholar] [CrossRef]
- Voigt, P.E.; Blakemore, J.K.; McCulloh, D.; Fino, M.E. Equal opportunity for all? An analysis of race and ethnicity in fertility preservation in New York City. J. Assist. Reprod. Genet. 2020, 37, 3095–3102. [Google Scholar] [CrossRef] [PubMed]
- Yoo, W.; Kim, S.; Huh, W.K.; Dilley, S.; Coughlin, S.S.; E Partridge, E.; Chung, Y.; Dicks, V.; Lee, J.-K.; Bae, S. Recent trends in racial and regional disparities in cervical cancer incidence and mortality in United States. PLoS ONE 2017, 12, e0172548. [Google Scholar] [CrossRef]
- Jiang, Y.; Liang, G.; Cao, Y. Trends in mortality rates associated with multiple myeloma in the United States, 1999–2023. Front. Oncol. 2025, 15, 1735565. [Google Scholar] [CrossRef] [PubMed]
- Merkison, J.M.; Chada, A.R.; Marsidi, A.M.; Spencer, J.B. Racial and ethnic disparities in assisted reproductive technology: A systematic review. Fertil. Steril. 2023, 119, 341–347. [Google Scholar] [CrossRef]
- Beroukhim, G.; Mahabamunuge, J.; Pal, L. Racial disparities in access to reproductive health and fertility care in the United States. Curr. Opin. Obstet. Gynecol. 2022, 34, 138–146. [Google Scholar] [CrossRef]
- Huddleston, A.; Ray, K.; Bacani, R.; Staggs, J.; Anderson, R.M.; Vassar, M. Inequities in Medically Assisted Reproduction: A Scoping Review. Reprod. Sci. 2023, 30, 2373–2396. [Google Scholar] [CrossRef]
- Seifer, D.B.; Sharara, F.I.; Jain, T. The Disparities in ART (DART) Hypothesis of Racial and Ethnic Disparities in Access and Outcomes of In Vitro Fertilization (IVF) Treatment in the United States: A Blueprint for Narrowing the Disparity Gap. In Racial and Ethnic Disparities in Fertility and Assisted Reproduction; Sharara, F.I., Seifer, D.B., Eds.; Springer Nature: Cham, Switzerland, 2025; pp. 1–8. [Google Scholar] [CrossRef]
- Covelli, A.; Facey, M.; Kennedy, E.; Brezden-Masley, C.; Gupta, A.A.; Greenblatt, E.; Baxter, N.N. Clinicians’ Perspectives on Barriers to Discussing Infertility and Fertility Preservation With Young Women with Cancer. JAMA Netw. Open 2019, 2, e1914511. [Google Scholar] [CrossRef]
- Vest, A.N.; Kuete, N.T.; Mehta, A. Is fertility preservation a part of comprehensive cancer care in the USA? A study of NCI-designated cancer center websites. J. Cancer Surviv. 2021, 15, 906–911. [Google Scholar] [CrossRef]
- Jones, G.; Hughes, J.; Mahmoodi, N.; Smith, E.; Skull, J.; Ledger, W. What factors hinder the decision-making process for women with cancer and contemplating fertility preservation treatment? Hum. Reprod. Update 2017, 23, 433–457. [Google Scholar] [CrossRef] [PubMed]
- Peate, M.; Meiser, B.; Cheah, B.C.; Saunders, C.; Butow, P.; Thewes, B.; Hart, R.; Phillips, K.-A.; Hickey, M.; Friedlander, M. Making hard choices easier: A prospective, multicentre study to assess the efficacy of a fertility-related decision aid in young women with early-stage breast cancer. Br. J. Cancer 2012, 106, 1053–1061. [Google Scholar] [CrossRef]
- Shliakhtsitsava, K.; Stark, S.S.; Prasad, T.; Boles, S.; Chingos, D.; Ehren, J.; Gorman, J.R.; Romero, S.A.D.; Mao, J.J.; Nathan, P.; et al. Impact of a Reproductive Health Survivorship Care Plan on Fertility, Pregnancy Concerns, and Accessing Reproductive Healthcare Among Young Nulliparous Breast Cancer Survivors. Cancer Rep. 2026, 9, e70433. [Google Scholar] [CrossRef] [PubMed]
- Seifer, D.B.; Feinberg, E.C.; Hsu, A.L. Ovarian Aging and Fertility. JAMA 2024, 332, 1750. [Google Scholar] [CrossRef]
- Corona, L.E.; Bak, M.; Farje, D.; Rosoklija, I.; Kennedy, T.; Zarnegar-Lumley, S.; Lockart, B.A.; Meyer, T.; Kamanzi, S.; Hirsch, J.A.; et al. Formal Fertility Preservation Program Facilitates Equitable Fertility Care Among Pediatric Oncology and Stem Cell Transplant Patients. J. Pediatr. Surg. 2025, 60, 162400. [Google Scholar] [CrossRef]
- Peavey, M.; Arian, S.; Gibbons, W.; Lu, K.; Gershenson, D.; Woodard, T. On-Site Fertility Preservation Services for Adolescents and Young Adults in a Comprehensive Cancer Center. J. Adolesc. Young Adult Oncol. 2017, 6, 229–234. [Google Scholar] [CrossRef] [PubMed]
- Zwingerman, R.; Melenchuk, K.; McMahon, E.; Liu, K.E.; Siren, A.; Laferriere, N.; Greenblatt, E.M. Expanding Urgent Oncofertility Services for Reproductive Age Women Remote from a Tertiary Level Fertility Centre by Use of Telemedicine and an On-site Nurse Navigator. J. Cancer Educ. 2020, 35, 515–521. [Google Scholar] [CrossRef] [PubMed]
- Polavarapu, M.; Arsene, C.; Singh, S.; Boakye Ansah, J. Fertility Preservation Among Patients With Breast Cancer: A Qualitative Study of Patient and Healthcare Provider Perspectives. Cureus 2025, 17, e89704. [Google Scholar] [CrossRef]
- Gorenshtein, A.; Perek, S.; Vaisbuch, Y.; Shelly, S. AI-generated neurology consultation summaries improve efficiency and reduce documentation burden in the emergency department. Sci. Rep. 2025, 15, 38868. [Google Scholar] [CrossRef]
- Korkidakis, A.; DeSantis, C.; Kissin, D.; Hacker, M.; Koniares, K.; Yartel, A.; Adashi, E.; Penzias, A. State insurance mandates and racial and ethnic inequities in assisted reproductive technology utilization. Fertil. Steril. 2024, 121, 54–62. [Google Scholar] [CrossRef]
- Bitler, M.; Schmidt, L. Health disparities and infertility: Impacts of state-level insurance mandates. Fertil. Steril. 2006, 85, 858–865. [Google Scholar] [CrossRef]
- Correia, K.F.B.; Kraschel, K.; Seifer, D.B. State insurance mandates for in vitro fertilization are not associated with improving racial and ethnic disparities in utilization and treatment outcomes. Am. J. Obstet. Gynecol. 2023, 228, 313.e1–313.e8. [Google Scholar] [CrossRef] [PubMed]
- Liao, C.; Kotlyar, A.M.; Seifer, D.B. Effect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies. Fertil. Steril. 2023, 120, 111–122. [Google Scholar] [CrossRef] [PubMed]
- Woods, B.M.; Bray, L.A.; Campbell, S.B.; Li, P.; Kazmerski, T.M.; Hovater, C.; Pitts, L.N.; Ladores, S. Implementation and evaluation of a fertility preservation telehealth counseling intervention for males with cystic fibrosis. J. Cyst. Fibros. 2024, 23, 658–663. [Google Scholar] [CrossRef] [PubMed]
- Willson, S.; Roberts, L.; Molinaro, T.; Bollig, K. Navigating fertility care in the telehealth era: Association of consultation mode with patient engagement and pregnancy outcomes. J. Assist. Reprod. Genet. 2025, 42, 3453–3460. [Google Scholar] [CrossRef] [PubMed]
- Lersten, I.; Fought, A.; Yannetsos, C.; Sheeder, J.; Roeca, C. Patient perspectives of telehealth for fertility care: A national survey. J. Assist. Reprod. Genet. 2023, 40, 1369–1376. [Google Scholar] [CrossRef]
- Peipert, B.J.; Potapragada, N.R.; Lantos, P.M.; Harris, B.S.; Reinecke, J.; Goldman, K.N. A Geospatial Analysis of Disparities in Access to Oncofertility Services. JAMA Oncol. 2023, 9, 1364. [Google Scholar] [CrossRef]
- Achalu, P.; Levine, S.L.; Crosson, F.J. Access to Fertility Preservation: A Policy Review on State-Level Mandates for Iatrogenic Infertility. Perm. J. 2025, 29, 73–79. [Google Scholar] [CrossRef]
- Flores Ortega, R.E.; Yoeun, S.W.; Mesina, O.; Kaiser, B.N.; McMenamin, S.B.; Su, H.I. Assessment of Health Insurance Benefit Mandates for Fertility Preservation Among 11 US States. JAMA Health Forum 2021, 2, e214309. [Google Scholar] [CrossRef] [PubMed]
- Yeshua, A.S.; Abittan, B.; Bar-El, L.; Mullin, C.; Goldman, R.H. Employer-based insurance coverage increases utilization of planned oocyte cryopreservation. J. Assist. Reprod. Genet. 2022, 39, 1393–1397. [Google Scholar] [CrossRef]

| Main Identifiable Systemic Bottlenecks | Suggested Solutions |
|---|---|
| Delayed counseling or lack of counseling regarding the reproductive consequences of cancer treatment |
|
| Suboptimal referral rates |
|
| Reduced rates of ART access and utilization in underrepresented groups |
|
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Share and Cite
Mahabamunuge, J.; Seifer, D.B. Racial and Ethnic Disparities in Fertility Preservation for Women with Cancer in the United States—Identifying Systemic Barriers and Proposing Solutions Through the DART Hypothesis. Cancers 2026, 18, 828. https://doi.org/10.3390/cancers18050828
Mahabamunuge J, Seifer DB. Racial and Ethnic Disparities in Fertility Preservation for Women with Cancer in the United States—Identifying Systemic Barriers and Proposing Solutions Through the DART Hypothesis. Cancers. 2026; 18(5):828. https://doi.org/10.3390/cancers18050828
Chicago/Turabian StyleMahabamunuge, Jasmin, and David B. Seifer. 2026. "Racial and Ethnic Disparities in Fertility Preservation for Women with Cancer in the United States—Identifying Systemic Barriers and Proposing Solutions Through the DART Hypothesis" Cancers 18, no. 5: 828. https://doi.org/10.3390/cancers18050828
APA StyleMahabamunuge, J., & Seifer, D. B. (2026). Racial and Ethnic Disparities in Fertility Preservation for Women with Cancer in the United States—Identifying Systemic Barriers and Proposing Solutions Through the DART Hypothesis. Cancers, 18(5), 828. https://doi.org/10.3390/cancers18050828
