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Retraction

RETRACTED: Gravina et al. The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models. Cancers 2019, 11, 1604

1
Department of Biotechnological and Applied Clinical Sciences, Division of Radiation Oncology, University of L’Aquila, 67100 L’Aquila, Italy
2
Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L’Aquila, 67100 L’Aquila, Italy
3
Department of Biotechnological and Applied Clinical Sciences, Laboratory of Cellular Biology, University of L’Aquila, 67100 L’Aquila, Italy
4
Department of Biotechnological and Applied Clinical Sciences, Laboratory of Human Anatomy, University of L’Aquila, 67100 L’Aquila, Italy
5
Department of Biotechnological and Applied Clinical Sciences, Laboratory of Neurophysiology, University of L’Aquila, 67100 L’Aquila, Italy
6
Laboratory of Experimental Medicine and Environmental Pathology, University Hub “Sabina Universitas”, 02100 Rieti, Italy
7
Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00118 Rome, Italy
8
Department of Biotechnological and Applied Clinical Sciences, Laboratory of Experimental Oncology, University of L’Aquila, 67100 L’Aquila, Italy
9
Sherris Pharma Partners, Jamaica Plain, MA 02130, USA
*
Author to whom correspondence should be addressed.
Cancers 2026, 18(1), 122; https://doi.org/10.3390/cancers18010122 (registering DOI)
Submission received: 23 December 2025 / Accepted: 25 December 2025 / Published: 30 December 2025
The journal retracts the article, “The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models” [1], cited above.
Following publication, concerns were brought to the attention of the Editorial Office regarding the duplication or partial overlap between a sub-image in Figure 6 [1] and sub-images in Figure 5 in another publication [2] with partially overlapping authorship.
Adhering to our standard procedure, an investigation was conducted by the Editorial Office and the Editorial Board that confirmed two partial overlaps and one duplication between Figure 6 in this publication [1] and sub-figures included in Figure 6 in another paper [2]. While the authors provided replacement images during the investigation, the Editorial Board found the explanations regarding the duplicated data insufficient to warrant a correction. Consequently, the Editorial Board has lost confidence in the reliability of the findings and decided to retract this publication [1], as per MDPI’s retraction policy (https://www.mdpi.com/ethics#_bookmark30).
This retraction was approved by the Editor-in-Chief of the Cancers journal.
The authors did not provide a comment on this decision.
The corresponding author, Claudio Festuccia, takes full responsibility for the concerns raised and clarifies that the other co-authors were not directly involved in the duplication of the figures in question.

References

  1. Gravina, G.L.; Mancini, A.; Colapietro, A.; Delle Monache, S.; Sferra, R.; Pompili, S.; Vitale, F.; Martellucci, S.; Marampon, F.; Mattei, V.; et al. RETRACTED: The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models. Cancers 2019, 11, 1604. [Google Scholar] [CrossRef] [PubMed]
  2. Gravina, G.L.; Mancini, A.; Colapietro, A.; Delle Monache, S.; Sferra, R.; Vitale, F.; Cristiano, L.; Martellucci, S.; Marampon, F.; Mattei, V.; et al. The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models. Cancers 2019, 11, 359. [Google Scholar] [CrossRef] [PubMed]
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Share and Cite

MDPI and ACS Style

Gravina, G.L.; Mancini, A.; Colapietro, A.; Delle Monache, S.; Sferra, R.; Pompili, S.; Vitale, F.; Martellucci, S.; Marampon, F.; Mattei, V.; et al. RETRACTED: Gravina et al. The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models. Cancers 2019, 11, 1604. Cancers 2026, 18, 122. https://doi.org/10.3390/cancers18010122

AMA Style

Gravina GL, Mancini A, Colapietro A, Delle Monache S, Sferra R, Pompili S, Vitale F, Martellucci S, Marampon F, Mattei V, et al. RETRACTED: Gravina et al. The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models. Cancers 2019, 11, 1604. Cancers. 2026; 18(1):122. https://doi.org/10.3390/cancers18010122

Chicago/Turabian Style

Gravina, Giovanni Luca, Andrea Mancini, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Simona Pompili, Flora Vitale, Stefano Martellucci, Francesco Marampon, Vincenzo Mattei, and et al. 2026. "RETRACTED: Gravina et al. The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models. Cancers 2019, 11, 1604" Cancers 18, no. 1: 122. https://doi.org/10.3390/cancers18010122

APA Style

Gravina, G. L., Mancini, A., Colapietro, A., Delle Monache, S., Sferra, R., Pompili, S., Vitale, F., Martellucci, S., Marampon, F., Mattei, V., Biordi, L., Sherris, D., & Festuccia, C. (2026). RETRACTED: Gravina et al. The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models. Cancers 2019, 11, 1604. Cancers, 18(1), 122. https://doi.org/10.3390/cancers18010122

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