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Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes
 
 
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Correction to Cancers 2025, 17(13), 2211.
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Correction

Correction: Chen et al. Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes. Cancers 2025, 17, 2211

by
Hsin-Yu Chen
1,*,
Ivan de Kouchkovsky
2,
Robert A. Bok
1,2,
Michael A. Ohliger
1,
Zhen J. Wang
1,
Daniel Gebrezgiabhier
1,
Tanner Nickles
1,
Lucas Carvajal
1,
Jeremy W. Gordon
1,
Peder E. Z. Larson
1,
John Kurhanewicz
1,2,
Rahul Aggarwal
2 and
Daniel B. Vigneron
1,2
1
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
2
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA
*
Author to whom correspondence should be addressed.
Cancers 2025, 17(15), 2511; https://doi.org/10.3390/cancers17152511
Submission received: 15 July 2025 / Accepted: 16 July 2025 / Published: 30 July 2025
(This article belongs to the Special Issue Prostate Cancer: Molecular Imaging and Magnetic Resonance Imaging (MRI))
Browse Figures
Versions Notes

Error in Figure

In the original publication [1], there was a mistake in Figures 2 and 5 as published. Figures with an old, obsolete kPL unit (s−1) were erroneously uploaded during editing and proofreading. These figures are now corrected and have been replaced with kPL unit ks−1, which is the preferable style. The corrected Figure 2 and Figure 5 appear below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

  1. Chen, H.-Y.; de Kouchkovsky, I.; Bok, R.A.; Ohliger, M.A.; Wang, Z.J.; Gebrezgiabhier, D.; Nickles, T.; Carvajal, L.; Gordon, J.W.; Larson, P.E.Z.; et al. Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes. Cancers 2025, 17, 2211. [Google Scholar] [CrossRef] [PubMed]
Cancers 17 02511 g002
Figure 2. HP multiparametric features of metabolism (MFM) kPL,median was selected and applied to univariate Cox proportional hazards model. (A) Kaplan–Meier analysis revealed substantially longer PFS and OS in patients with kPL,median ≤ 17 ks−1 (median PFS: 11.2 vs. 0.5 months; median OS: NR vs. 18.4 months). (B) Example cases illustrating metastatic prostate cancer patients with kPL,median higher and lower than the dichotomized cutoff value of 17. The patient on the left had high-volume liver metastases with kPL,median = 24.8, whereas on the right had low or undetectable kPL,median across the osseous pelvic metastases. Images shown were kPL heatmaps overlaid on 1H T1-FSPGR references. * p < 0.05, ** p < 0.01.
Figure 2. HP multiparametric features of metabolism (MFM) kPL,median was selected and applied to univariate Cox proportional hazards model. (A) Kaplan–Meier analysis revealed substantially longer PFS and OS in patients with kPL,median ≤ 17 ks−1 (median PFS: 11.2 vs. 0.5 months; median OS: NR vs. 18.4 months). (B) Example cases illustrating metastatic prostate cancer patients with kPL,median higher and lower than the dichotomized cutoff value of 17. The patient on the left had high-volume liver metastases with kPL,median = 24.8, whereas on the right had low or undetectable kPL,median across the osseous pelvic metastases. Images shown were kPL heatmaps overlaid on 1H T1-FSPGR references. * p < 0.05, ** p < 0.01.
Cancers 17 02511 g002
Cancers 17 02511 g005
Figure 5. Hypothesis-generating multivariate survival analyses using (A) metabolic prognostic score (MPS) derived from multivariate Cox proportional hazards model, adjusted for patient age. (B) MPS was significantly associated with both PFS (p < 0.002) and OS (p < 0.05), with longer median PFS (NR vs. 2.4 months) and OS (NR vs. 18.4 months) for lower-MPS vs. higher-MPS patients, dichotomized by the cohort median MPS = −0.581. * p < 0.05, ** p < 0.01.
Figure 5. Hypothesis-generating multivariate survival analyses using (A) metabolic prognostic score (MPS) derived from multivariate Cox proportional hazards model, adjusted for patient age. (B) MPS was significantly associated with both PFS (p < 0.002) and OS (p < 0.05), with longer median PFS (NR vs. 2.4 months) and OS (NR vs. 18.4 months) for lower-MPS vs. higher-MPS patients, dichotomized by the cohort median MPS = −0.581. * p < 0.05, ** p < 0.01.
Cancers 17 02511 g005
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MDPI and ACS Style

Chen, H.-Y.; de Kouchkovsky, I.; Bok, R.A.; Ohliger, M.A.; Wang, Z.J.; Gebrezgiabhier, D.; Nickles, T.; Carvajal, L.; Gordon, J.W.; Larson, P.E.Z.; et al. Correction: Chen et al. Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes. Cancers 2025, 17, 2211. Cancers 2025, 17, 2511. https://doi.org/10.3390/cancers17152511

AMA Style

Chen H-Y, de Kouchkovsky I, Bok RA, Ohliger MA, Wang ZJ, Gebrezgiabhier D, Nickles T, Carvajal L, Gordon JW, Larson PEZ, et al. Correction: Chen et al. Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes. Cancers 2025, 17, 2211. Cancers. 2025; 17(15):2511. https://doi.org/10.3390/cancers17152511

Chicago/Turabian Style

Chen, Hsin-Yu, Ivan de Kouchkovsky, Robert A. Bok, Michael A. Ohliger, Zhen J. Wang, Daniel Gebrezgiabhier, Tanner Nickles, Lucas Carvajal, Jeremy W. Gordon, Peder E. Z. Larson, and et al. 2025. "Correction: Chen et al. Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes. Cancers 2025, 17, 2211" Cancers 17, no. 15: 2511. https://doi.org/10.3390/cancers17152511

APA Style

Chen, H.-Y., de Kouchkovsky, I., Bok, R. A., Ohliger, M. A., Wang, Z. J., Gebrezgiabhier, D., Nickles, T., Carvajal, L., Gordon, J. W., Larson, P. E. Z., Kurhanewicz, J., Aggarwal, R., & Vigneron, D. B. (2025). Correction: Chen et al. Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes. Cancers 2025, 17, 2211. Cancers, 17(15), 2511. https://doi.org/10.3390/cancers17152511

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