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Sentinel Lymph Node Assessment in Endometrial Cancer: A Review
 
 
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Cancers
Volume 16
Issue 23
10.3390/cancers16234035
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Article
Peer-Review Record

Evaluation of Different Risk Factors for Metastatic Sentinel Lymph Nodes in Endometrial Cancer

Cancers 2024, 16(23), 4035; https://doi.org/10.3390/cancers16234035
by Michele Peiretti 1, Alfonso Altieri 1,*, Giorgio Candotti 2, Giuseppina Fais 1, Andrea Ungredda 1, Valerio Mais 1, Daniela Fanni 3 and Stefano Angioni 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cancers 2024, 16(23), 4035; https://doi.org/10.3390/cancers16234035
Submission received: 10 October 2024 / Revised: 7 November 2024 / Accepted: 28 November 2024 / Published: 1 December 2024
(This article belongs to the Special Issue Clinical Research Advances in Endometrial Carcinoma)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

Assessing risk factors are getting complicated after new EM cancer staging regarding adjuvant treatment. I recommend minor revision.

1.    Any pathological picture and difference explanation about MAC, MIC, ITC is needed. High resolution is recommended.

2.    How about preoperative imaging modality to find any high-risk portion of patients? MRI/PET-CT all included?

3.    It would be helpful to understand trends of national /institutional adjuvant treatment guideline and immune target treatment reimbursement/MMR IHC or adoption of NGS panel for this population during year 2015-2024.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

Please find my comments below:

1. Please provide the country for the Bioethical Committee.

2. Please provide a sample size analysis.

3. Only one limitation?

4. Please clearly state the number of cases for each G in the abstract and main text.

5. References were not prepared according to the journal's requirements.

6. Please provide the novelty of the study in the introduction.

7. Please describe if and how molecular analysis could help predict advances in EC and the risk of metastasis. Could you consider using and citing the paper, doi: 10.3390/ijms23031237?

8. In the M&M section, please add the sub-section about study design and how patients' data was confidented.

9. Consider changing some tables to figures. 

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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