Metabolic Tumor Volume from 18F-FDG PET/CT in Combination with Radiologic Measurements to Predict Long-Term Survival Following Transplantation for Colorectal Liver Metastases
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patient Selection
2.2. Imaging Procedure and Image Assessments
2.3. Statistical Analysis
3. Results
3.1. Patient and Baseline Characteristics
3.2. Overall Survival Analysis
3.3. Disease-Free Survival Analysis
3.4. Survival after Relapse Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients, n | 45 |
---|---|
Age at liver transplantation (LT), years + | 58 (29–71) |
Gender, n (%) | |
Male | 24 (53) |
Female | 21 (47) |
Primary tumor, n (%) | |
Colon | 27 (60) |
Rectum | 18 (40) |
T Stage, n (%) | |
0 | 3 (6) |
1 | 1 (2) |
2 | 5 (10) |
3 | 35 (78) |
4 | 1 (2) |
N Stage, n (%) | |
0 | 21 (47) |
1 | 16 (36) |
2 | 8 (18) |
Progressive disease at LT, n (%) * | |
Yes | 16 (36) |
No | 29 (64) |
Metabolic tumor volume (MTV), cm3 + | 21.3 (0–874.12) |
Carcinoembryonic antigen (CEA), µg/L + | 5 (1–2002) |
Number of metastases, n + | 7 (1–53) |
Largest metastasis (mm) + | 30 (3–130) |
Group | Disease-Free Survival | |||||||
---|---|---|---|---|---|---|---|---|
MTV Low | MTV High | |||||||
1 Year | 3 Years | 5 Years | 1 Year | 3 Years | 5 Years | p-Value | ||
Number of metastases | Low (≤8) | 59 | 41% | 34% | 17% | 0% | 0% | 0.010 |
High (>8) | 44% | 33% | 22% | 25% | 0% | 0% | 0.034 | |
Size of the largest metastasis | Low (<5.5 cm) | 55% | 39% | 29% | 25% | 0% | 0% | 0.002 |
High (>5.5 cm) | n = 0 | 22% | 0% | 0% | ||||
Tumor burden score | Group 2 | 62% | 43% | 36% | 50% | 0% | 0% | 0.086 |
Group 3 | 40% | 30% | 20% | 17% | 0% | 0% | 0.034 |
Group | Survival after Relapse | |||||
---|---|---|---|---|---|---|
MTV Low | MTV High | |||||
5 Years | 10 Years | 5 Years | 10 Years | p-Value | ||
Number of metastases | Low (≤8) | 54% | 39% | 17% | 0% | 0.144 |
High (>8) | 57% | 19% | 13% | 0% | 0.026 | |
Size of the largest metastasis | Low (<5.5 cm) | 60% | 31% | 25% | 0% | 0.749 |
High (>5.5 cm) | n = 0 | 11% | 0% | |||
Tumor burden score | Group 2 | 50% | 42% | n = 2 | 0.604 | |
Group 3 | 75% | 16% | 8% | 0% | 0.006 |
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Grut, H.; Line, P.-D.; Syversveen, T.; Dueland, S. Metabolic Tumor Volume from 18F-FDG PET/CT in Combination with Radiologic Measurements to Predict Long-Term Survival Following Transplantation for Colorectal Liver Metastases. Cancers 2024, 16, 19. https://doi.org/10.3390/cancers16010019
Grut H, Line P-D, Syversveen T, Dueland S. Metabolic Tumor Volume from 18F-FDG PET/CT in Combination with Radiologic Measurements to Predict Long-Term Survival Following Transplantation for Colorectal Liver Metastases. Cancers. 2024; 16(1):19. https://doi.org/10.3390/cancers16010019
Chicago/Turabian StyleGrut, Harald, Pål-Dag Line, Trygve Syversveen, and Svein Dueland. 2024. "Metabolic Tumor Volume from 18F-FDG PET/CT in Combination with Radiologic Measurements to Predict Long-Term Survival Following Transplantation for Colorectal Liver Metastases" Cancers 16, no. 1: 19. https://doi.org/10.3390/cancers16010019