Precision Surgery of Colorectal Liver Metastases in the Current Era: A Systematic Review
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Literature Search and Strategy
2.2. Outcomes of Interest, Data Extraction and Synthesis
2.3. Inclusion and Exclusion Criteria
3. Results
3.1. Anatomical Versus Non-Anatomical Resections
3.2. R1 Resection Rates in Mutated and Wild-Type RAS Patients
3.3. Impact of RAS Status on Survival after Incomplete Resection
4. Discussion
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Study | Year of Publication | Country of Origin | Type of Study | Total Number of Patients | mutRAS, n (%) | Synchronous Presentation, n (%) | Number of Tumors (Median, Range) | Tumor Size (Median, Range) | Extrahepatic Disease, n (%) |
---|---|---|---|---|---|---|---|---|---|
Choi et al. [18] | 2022 | Korean | Retrospective | 250 | 94 (37.6) | 250 (100) | 2.85 ± 3.00 * | 2.37 ± 1.80 * | 0 |
Kawai et al. [19] | 2022 | Japan | Retrospective | 290 | 104 (35.9) | 167 (57.6) | 1.6 ± 1.7 * | 2.5 ± 2.5 * | NR |
Joechle et al. [20] | 2019 | USA | Retrospective, PSM | 360 | 150 (41.7) | 253 (70) | 1 (1–9) | 2 (0.1–9.5) | 55 (15) |
Margonis et al. [16] | 2017 | USA | Retrospective | 389 | 140 (35.9) | 223 (57.3) | 2 (1–3) | 2.5 (1.6–4.0) | NR |
Brudvik et al. [14] | 2016 | USA | Retrospective | 633 | 229 (36.2) | 446 (70.5) | NR | NR | NR |
Zhang et al. [15] | 2020 | China | Retrospective | 251 | 130 (51.8) | 61 (24) | NR | NR | 28 (11.2) |
Hatta et al. [21] | 2020 | UK | Retrospective | 500 | 152 (30.4) | 233 (51.7) | 2 (1–3) | 3 (2–5) | NR |
Margonis et al. [3] | 2016 | USA | Retrospective | 485 | 178 (36.7) | 277 (57.1) | 2 (1–3) | 2.5 (1.5–4) | NR |
Xu et al. [22] | 2019 | China | Retrospective | 214 | 100 (46.7) | NR | NR | NR | NR |
Procopio et al. [23] | 2020 | Italy | Retrospective | 340 | 150 (44.1) | NR | NR | NR | NR |
Anatomic vs. Non-Anatomic | ||||||
---|---|---|---|---|---|---|
mutRAS | wtRAS | |||||
Study | LS-DFS Hazard Ratio | 5-Year LS-DFS (%) | p-Value | LS-DFS Hazard Ratio | 5-Year LS-DFS (%) | p-Value |
Choi et al. [18] | 1.23 (0.64–2.39) | NR | 0.52 | 1.41 (0.86–2.32) | NR | 0.17 |
Kawai et al. [19] | NR | NR | 0.23 | 0.42 (0.25–0.72) | NR | 0.001 |
Joechle et al. [20] | NR | 16 vs. 17.3 | 0.4 | NR | 22.9 vs. 14.3 | 0.88 |
Margonis et al. [16] | 0.37 (0.21–0.64) | 13 vs. 0 | <0.001 | 0.63 (0.42–0.94) | 15.9 vs. 4.3 | 0.02 |
mutRAS | wtRAS | ||||
---|---|---|---|---|---|
Study | Total Patients | R1, n (%) | Total Patients | R1, n (%) | p-Value |
Brudvik et al. [14] | 229 | 26 (11.4) | 404 | 22 (5.4) | 0.007 |
Choi et al. [18] | 94 | 3 (3.2) | 156 | 4 (2.6) | 0.55 |
Hatta et al. [21] | 146 | 42 (28.8) | 284 | 84 (29.6) | 0.88 |
Margonis et al. [16] | 178 | 35 (19.7) | 307 | 70 (22.8) | 0.49 |
Xu et al. [22] | 100 | 41 (41) | 114 | 26 (22.8) | 0.005 |
Zhang et al. [15] | 117 | 26 (21.5) | 130 | 12 (9.2) | 0.007 |
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Papaconstantinou, D.; Pararas, N.; Pikouli, A.; Nastos, C.; Charalampopoulos, A.; Dellaportas, D.; Bagias, G.; Pikoulis, E. Precision Surgery of Colorectal Liver Metastases in the Current Era: A Systematic Review. Cancers 2023, 15, 2083. https://doi.org/10.3390/cancers15072083
Papaconstantinou D, Pararas N, Pikouli A, Nastos C, Charalampopoulos A, Dellaportas D, Bagias G, Pikoulis E. Precision Surgery of Colorectal Liver Metastases in the Current Era: A Systematic Review. Cancers. 2023; 15(7):2083. https://doi.org/10.3390/cancers15072083
Chicago/Turabian StylePapaconstantinou, Dimitrios, Nikolaos Pararas, Anastasia Pikouli, Constantinos Nastos, Anestis Charalampopoulos, Dionysios Dellaportas, George Bagias, and Emmanouil Pikoulis. 2023. "Precision Surgery of Colorectal Liver Metastases in the Current Era: A Systematic Review" Cancers 15, no. 7: 2083. https://doi.org/10.3390/cancers15072083