Value of Cellular Components and Focal Dedifferentiation to Predict the Risk of Metastasis in a Benign-Appearing Extra-Meningeal Solitary Fibrous Tumor: An Original Series from a Tertiary Sarcoma Center
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Patients
2.2. Statistical Analysis
3. Results
3.1. Patients
3.2. Distant Metastasis
3.3. Patient Survival
3.4. Risk Assessment Tools
3.5. Dedifferentiated SFT
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Median (Range) | N (VP%) | Mean (SD) |
---|---|---|---|
Age (Y) | 59 (27–81) | ||
Gender | |||
male | 27 (53%) | ||
female | 24 (47%) | ||
Tumor location | |||
Extremity/intramuscular | 20 (39%) | ||
Retroperitoneum/viscera | 18 (35%) | ||
Intra-thoracic | 13 (25%) | ||
Follow-up (m) | 60 (11–120) | ||
Tumor size (cm) | 5.5 (1.1–23) | 7.61 (5.03) | |
Necrosis | 11 (23.4%) | ||
Cellularity | 17 (42.5%) | ||
Atypia | 18 (39.1%) | ||
Mitosis (10HPF) | 2.5 (0–22) | 4.15 (4.9) | |
Demicco’s risk score | |||
low | 32 (62.7%) | ||
Intermediate | 13 (25.5%) | ||
High | 12 (32.4%) | ||
Pasquali’s risk score (extra pleural SFT) | |||
Very low/low | 27 (72.9) | ||
Intermediate | 5 (13.5) | ||
High | 12 (32.4) |
Variables | Metastasis | HR (CI 95%) | 5YDF Survival | HR (CI 95%) |
---|---|---|---|---|
Age (continuous) | p = 0.20 | p = 0.12 | ||
Age (categorical) | p = 0.82 | p = 0.45 | ||
Hypercellularity | p = 0.001 | p = 0.41 | ||
Size | p = 0.001 | 1.21 (1.08–1.35) | p = 0.01 | 0.79 (0.67–0.94) |
Mitotic activity | p = 0.003 | 1.2 (1.06–1.34) | p = 0.38 | |
Demicco score | p = 0.007 | 1.62 (1.14–2.3) | p = 0.019 | 1.63 (1.08–2.45) |
Local recurrence | p = 0.003 | 12.68 (2.31–69.5) |
Case | Age | Location | Size cm | Mitosis 10HPF | Hyper Cellular | Demicco Risk Group | Dedifferentiated Nodule Histology |
---|---|---|---|---|---|---|---|
1 | 31 | Paraspinal muscle | 7.5 | 2 | Yes | Low | Scattered epithelioid/rhabdoid change, negative CD34 |
2 | 59 | Pre-sacral | 14 | 10 | ND | Int. | Focal high-grade dedifferentiated sarcoma, negative CD34 |
3 | 56 | Pleura | 11 | 13 | Yes | Int. | Focal rhabdoid change |
4 | 41 | Paraspinal muscle | 8.5 | 5 | ND | Low | Focal myxoid/epithelioid change, negative CD34 |
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Hassani, M.; Jung, S.; Ghodsi, E.; Seddigh, L.; Kooner, P.; Aoude, A.; Turcotte, R. Value of Cellular Components and Focal Dedifferentiation to Predict the Risk of Metastasis in a Benign-Appearing Extra-Meningeal Solitary Fibrous Tumor: An Original Series from a Tertiary Sarcoma Center. Cancers 2023, 15, 1441. https://doi.org/10.3390/cancers15051441
Hassani M, Jung S, Ghodsi E, Seddigh L, Kooner P, Aoude A, Turcotte R. Value of Cellular Components and Focal Dedifferentiation to Predict the Risk of Metastasis in a Benign-Appearing Extra-Meningeal Solitary Fibrous Tumor: An Original Series from a Tertiary Sarcoma Center. Cancers. 2023; 15(5):1441. https://doi.org/10.3390/cancers15051441
Chicago/Turabian StyleHassani, Mohammad, Sungmi Jung, Elaheh Ghodsi, Leila Seddigh, Paul Kooner, Ahmed Aoude, and Robert Turcotte. 2023. "Value of Cellular Components and Focal Dedifferentiation to Predict the Risk of Metastasis in a Benign-Appearing Extra-Meningeal Solitary Fibrous Tumor: An Original Series from a Tertiary Sarcoma Center" Cancers 15, no. 5: 1441. https://doi.org/10.3390/cancers15051441
APA StyleHassani, M., Jung, S., Ghodsi, E., Seddigh, L., Kooner, P., Aoude, A., & Turcotte, R. (2023). Value of Cellular Components and Focal Dedifferentiation to Predict the Risk of Metastasis in a Benign-Appearing Extra-Meningeal Solitary Fibrous Tumor: An Original Series from a Tertiary Sarcoma Center. Cancers, 15(5), 1441. https://doi.org/10.3390/cancers15051441