Management of the Contralateral Neck in Unilateral Node-Positive Oral Squamous Cell Carcinoma
Abstract
:Simple Summary
Abstract
1. Introduction
2. Material and Methods
2.1. Ethical Approval
2.2. Study Design
- I.
- Histologically proven OSCC, which was unilaterally located without reaching the midline. All patients underwent ipsilateral neck dissection (ND) and presented with histologically proven ipsilateral CLNM (≥pN1).
- II.
- The contralateral neck was determined to be clinically unsuspicious (cN0).
- III.
- Patients either receiving END for the contralateral neck (group I) or no surgical treatment for the contralateral neck (group II).
- IV.
- No history of previous OSCC or radiation therapy in the head and neck area.
- V.
- All patients underwent surgery with a curative intent and were treated with bilateral adjuvant radiotherapy (RT) with or without chemotherapy according to the national guidelines [4].
- VI.
- The minimum follow-up period was 6 months.
2.3. Statistical Analysis
3. Results
3.1. Patient Baseline Data
3.2. Lymph Node Management
3.3. Histopathological Examination
3.4. Follow-Up and Disease Recurrence
3.5. Occurrence of Contralateral CLNM in Ipsilateral N+ Necks during Follow-Up
3.6. Survival Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group I (Contralateral ND; n = 16, 24.6%) | Group II (No Contralateral ND; n = 49, 75.4%) | p-Value | |
---|---|---|---|
Gender | 0.59 | ||
Female | 5 (31.3%) | 19 (38.8%) | |
Male | 11 (68.7%) | 30 (61.2%) | |
Age in years (mean) | 62.9 (±7.0) | 62.4 (±12.3) | 0.89 |
Alcohol & Tobacco | 0.12 | ||
Yes | 12 (75.0%) | 26 (53.1%) | |
No | 4 (25.0%) | 23 (46.9%) | |
cT Stage | 0.15 | ||
cT1–2 | 7 (43.8%) | 32 (65.3%) | |
cT3–4 | 9 (56.2%) | 17 (34.7%) | |
Ipsilateral cN Stage | 0.93 | ||
cN0 | 7 (43.8%) | 18 (36.7%) | |
cN1 | 4 (25.0%) | 12 (24.5%) | |
cN2a | 2 (12.5%) | 6 (12.2%) | |
cN2b | 3 (18.8%) | 13 (26.5%) |
Group I (Contralateral ND; n = 16, 24.6%) | Group II (No Contralateral ND; n = 49, 75.4%) | p-Value | |
---|---|---|---|
pT Stage | 0.52 | ||
pT1–2 | 7 (43.8%) | 26 (53.1%) | |
pT3–4 | 9 (56.2%) | 23 (46.9%) | |
pN Stage | |||
pN1 | 9 (56.2%) | 12 (24.5%) | |
pN2a | 0 | 0 | |
pN2b | 2 (12.5%) | 22 (44.9%) | |
pN2c | 0 | 0 | |
pN3a | 0 | 0 | |
pN3b | 5 (31.3%) | 15 (30.6%) | |
ECS | 0.96 | ||
Yes | 5 (31.3%) | 15 (30.6%) | |
No | 11 (68.7%) | 34 (69.4%) | |
Grade of differentiation | 0.46 | ||
G1 | 0 | 2 (4.1%) | |
G2 | 14 (87.5%) | 36 (73.5%) | |
G3 | 2 (12.5%) | 11 (22.4%) | |
Depth of invasion (mean) | 12.0 (±7.4) | 10.8 (±6.6) | 0.57 |
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Doll, C.; Mrosk, F.; Freund, L.; Neumann, F.; Kreutzer, K.; Voss, J.; Raguse, J.-D.; Beck, M.; Böhmer, D.; Rubarth, K.; et al. Management of the Contralateral Neck in Unilateral Node-Positive Oral Squamous Cell Carcinoma. Cancers 2023, 15, 1088. https://doi.org/10.3390/cancers15041088
Doll C, Mrosk F, Freund L, Neumann F, Kreutzer K, Voss J, Raguse J-D, Beck M, Böhmer D, Rubarth K, et al. Management of the Contralateral Neck in Unilateral Node-Positive Oral Squamous Cell Carcinoma. Cancers. 2023; 15(4):1088. https://doi.org/10.3390/cancers15041088
Chicago/Turabian StyleDoll, Christian, Friedrich Mrosk, Lea Freund, Felix Neumann, Kilian Kreutzer, Jan Voss, Jan-Dirk Raguse, Marcus Beck, Dirk Böhmer, Kerstin Rubarth, and et al. 2023. "Management of the Contralateral Neck in Unilateral Node-Positive Oral Squamous Cell Carcinoma" Cancers 15, no. 4: 1088. https://doi.org/10.3390/cancers15041088
APA StyleDoll, C., Mrosk, F., Freund, L., Neumann, F., Kreutzer, K., Voss, J., Raguse, J. -D., Beck, M., Böhmer, D., Rubarth, K., Heiland, M., & Koerdt, S. (2023). Management of the Contralateral Neck in Unilateral Node-Positive Oral Squamous Cell Carcinoma. Cancers, 15(4), 1088. https://doi.org/10.3390/cancers15041088