Insights of Platinum Drug Interaction with Spinel Magnetic Nanocomposites for Targeted Anti-Cancer Effect
Abstract
:Simple Summary
Abstract
1. Introduction
2. Material and Methods
2.1. Preparation of 30% MnFe2O4/silica and GO
2.2. Cisplatin loading on MnFe2O4/silica and MnFe2O4/GO
2.3. Characterization Techniques
2.4. Drug Release Study
2.5. Computational Details
2.6. In Vitro Study
2.6.1. Cell Treatment
2.6.2. Cell Viability MTT Assay
2.6.3. Transmission Electron Microscopy (TEM)
2.6.4. Immunofluorescent and Light Microscopy
2.6.5. Annexin V/Propidium Iodide Analysis
2.6.6. Statistics
3. Results and Discussion
3.1. Characterization Studies
3.2. Drug Delivery Study
3.3. Theoretical Calculation of Cisplatin Interaction with silica and GO
3.4. In Vitro Cytotoxicity Studies
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Almohazey, D.; Ravinayagam, V.; Alamoudi, W.; Akhtar, S.; Dafalla, H.; AlSuwaidan, H.N.; Almutairi, S.T.; Alghamdi, H.S.; Aldamen, S.A.; Almessiere, M.A.; et al. Insights of Platinum Drug Interaction with Spinel Magnetic Nanocomposites for Targeted Anti-Cancer Effect. Cancers 2023, 15, 695. https://doi.org/10.3390/cancers15030695
Almohazey D, Ravinayagam V, Alamoudi W, Akhtar S, Dafalla H, AlSuwaidan HN, Almutairi ST, Alghamdi HS, Aldamen SA, Almessiere MA, et al. Insights of Platinum Drug Interaction with Spinel Magnetic Nanocomposites for Targeted Anti-Cancer Effect. Cancers. 2023; 15(3):695. https://doi.org/10.3390/cancers15030695
Chicago/Turabian StyleAlmohazey, Dana, Vijaya Ravinayagam, Widyan Alamoudi, Sultan Akhtar, H. Dafalla, Hind Nasser AlSuwaidan, Shoruq. T. Almutairi, Hajer Saleh Alghamdi, Sukaina Ahmed Aldamen, M. A. Almessiere, and et al. 2023. "Insights of Platinum Drug Interaction with Spinel Magnetic Nanocomposites for Targeted Anti-Cancer Effect" Cancers 15, no. 3: 695. https://doi.org/10.3390/cancers15030695