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Cancers
Volume 15
Issue 3
10.3390/cancers15030577
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Review
Peer-Review Record

MicroRNAs in the Pathogenesis, Prognostication and Prediction of Treatment Resistance in Soft Tissue Sarcomas

Cancers 2023, 15(3), 577; https://doi.org/10.3390/cancers15030577
by Andrea York Tiang Teo 1, Vivian Yujing Lim 2 and Valerie Shiwen Yang 2,3,4,*
Reviewer 1:
Michael J. Nathenson
Reviewer 2: Anonymous
Reviewer 3:
José M. Casanova
Cancers 2023, 15(3), 577; https://doi.org/10.3390/cancers15030577
Submission received: 24 November 2022 / Revised: 15 January 2023 / Accepted: 16 January 2023 / Published: 18 January 2023
(This article belongs to the Topic Soft Tissue Sarcomas: Treatment and Management)

Round 1

Reviewer 1 Report

Overall an excellent manuscript, and excellent review. Well presented and described, with good flow and conclusion. I would accept in its present form.

Author Response

Response to Reviewer 1:

Overall an excellent manuscript, and excellent review. Well presented and described, with good flow and conclusion. I would accept in its present form.

Author response: Thank you for your kind feedback.

Reviewer 2 Report

This represents an excellent, thorough, and well organized review on miRNA in STS. 

Author Response

Response to Reviewer 2:

This represents an excellent, thorough, and well organized review on miRNA in STS. 

Author response: Thank you for your kind feedback.

Reviewer 3 Report

Teo et al. revised the role of miRNAs in the pathogenesis, prognostication and in treatment resistance of soft tissue sarcomas (STS). They analyzed in detail the implications of miRNAs for the most frequent tumors (GIST, LPS, RMS, LMS and SS). For the treatment resistance, literature evidence is cited for imatinib, vincristine/entinostat and doxorubicin. The authors discussed the potential use and limitations of miRNA regarding the use in treatment of STS.

The manuscript is very well organized including explanatory figures and tables that facilitate the comprehension of this topic to the reader.

Minor correction

In Table 1 there is a full line under “Liposarcoma” that should be shortened in order to include “Inhibit” and “Promote” associated with “Liposarcoma”.

Author Response

Response to Reviewer 3:

Teo et al. revised the role of miRNAs in the pathogenesis, prognostication and in treatment resistance of soft tissue sarcomas (STS). They analyzed in detail the implications of miRNAs for the most frequent tumors (GIST, LPS, RMS, LMS and SS). For the treatment resistance, literature evidence is cited for imatinib, vincristine/entinostat and doxorubicin. The authors discussed the potential use and limitations of miRNA regarding the use in treatment of STS.

The manuscript is very well organized including explanatory figures and tables that facilitate the comprehension of this topic to the reader.

Minor correction

In Table 1 there is a full line under “Liposarcoma” that should be shortened in order to include “Inhibit” and “Promote” associated with “Liposarcoma”.

Author response: Thank you for your kind feedback. We have made the necessary changes to Table 1.

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