The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells
Abstract
:Simple Summary
Abstract
1. Introduction
1.1. Breast Cancer
1.2. HER2-Positive Breast Cancer
1.3. Triple-Negative Breast Cancer
1.4. Mammary Gland Development
1.5. Mammary Gland Stem Cell Niche
2. Cell Redirection
2.1. Cell Redirection by Mammary Microenvironments In Vivo
2.2. Cancer Cell Redirection
2.3. Differential Gene Expression in Mouse Mammary Microenvironment In Vitro
2.4. Cell Redirection by Mammary Microenvironment In Vitro
2.5. Phenotypic Changes Induced through In Vitro Redirection
2.6. Gene Expression Profile Changes In Vitro Redirection
3. Conclusions
4. Future Directions
Author Contributions
Funding
Conflicts of Interest
References
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Cells Transplanted | Ratio of Cancer Cells:MECs | # Positive Takes/# Implants | # Cancer Cell Takes/# Positive Takes | % Tumors |
---|---|---|---|---|
Mouse erbB2+ Cancer Cells Only | Cancer only | 0/18 | 0/0 | 100 |
Mouse erbB2+ Cancer Cells with MECs | 1:50 | 15/16 | 15/15 | 6.25 |
Human TC Cells Only | Cancer only | 0/6 | 0/0 | 33.3 |
Human TC Cells with MECs | 1:50 | 10/12 | 10/10 | 0 |
Human TNBC Cells with MECs | 1:5 | 5/20 | 5/5 | 50 |
Human TNBC Cells with MECs | 1:50 | 10/16 | 10/10 | 0 |
HER2+ Breast Cancer Cells Only | Cancer only | 0/4 | 0/0 | 100 |
HER2+ Breast Cancer Cells with MECs | 1:50 | 2/4 | 2/4 | 0 |
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Campbell, C.J.; Booth, B.W. The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells. Cancers 2023, 15, 576. https://doi.org/10.3390/cancers15030576
Campbell CJ, Booth BW. The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells. Cancers. 2023; 15(3):576. https://doi.org/10.3390/cancers15030576
Chicago/Turabian StyleCampbell, Caroline J., and Brian W. Booth. 2023. "The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells" Cancers 15, no. 3: 576. https://doi.org/10.3390/cancers15030576