Proton Reirradiation for High-Risk Recurrent or New Primary Breast Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Body
2.1. Toxicities of Reirradiation
2.2. Patient Selection and Rationale for Proton Therapy
2.3. Studies Investigating Proton ReRT for Breast Cancer
2.4. RBE/LET Considerations
2.5. Treatment Planning Approach and Considerations
2.6. Ongoing Trials Investigating Proton ReRT for Breast Cancer
2.7. Future Directions
3. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021, 71, 209–249. [Google Scholar] [CrossRef]
- Habbous, S.; Barisic, A.; Homenauth, E.; Kandasamy, S.; Forster, K.; Eisen, A.; Holloway, C. Estimating the incidence of breast cancer recurrence using administrative data. Breast Cancer Res. Treat. 2023, 198, 509–522. [Google Scholar] [CrossRef]
- Holleczek, B.; Stegmaier, C.; Radosa, J.C.; Solomayer, E.-F.; Brenner, H. Risk of loco-regional recurrence and distant metastases of patients with invasive breast cancer up to ten years after diagnosis—Results from a registry-based study from Germany. BMC Cancer 2019, 19, 520. [Google Scholar] [CrossRef]
- Pedersen, R.N.; Esen, B.Ö.; Mellemkjær, L.; Christiansen, P.; Ejlertsen, B.; Lash, T.L.; Nørgaard, M.; Cronin-Fenton, D. The Incidence of Breast Cancer Recurrence 10–32 Years After Primary Diagnosis. J. Natl. Cancer Inst. 2022, 114, 391–399. [Google Scholar] [CrossRef] [PubMed]
- Early Breast Cancer Trialists’ Collaborative, G.; Darby, S.; McGale, P.; Correa, C.; Taylor, C.; Arriagada, R.; Clarke, M.; Cutter, D.; Davies, C.; Ewertz, M.; et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 2011, 378, 1707–1716. [Google Scholar] [CrossRef]
- Ebctcg; McGale, P.; Taylor, C.; Correa, C.; Cutter, D.; Duane, F.; Ewertz, M.; Gray, R.; Mannu, G.; Peto, R.; et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: Meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet 2014, 383, 2127–2135. [Google Scholar] [CrossRef] [PubMed]
- Touati, R.; Pauly, L.; Reyal, F.; Kirova, Y. Breast Cancer and Mediastinal Hodgkin’s Lymphomas: Multidisciplinary Discussion. Clin. Breast Cancer 2023, 23, 681–686. [Google Scholar] [CrossRef]
- Abeloos, C.H.; Purswani, J.M.; Galavis, P.; McCarthy, A.; Hitchen, C.; Choi, J.I.; Gerber, N.K. Different Re-Irradiation Techniques after Breast-Conserving Surgery for Recurrent or New Primary Breast Cancer. Curr. Oncol. 2023, 30, 1151–1163. [Google Scholar] [CrossRef]
- Arthur, D.W.; Winter, K.A.; Kuerer, H.M.; Haffty, B.G.; Cuttino, L.W.; Todor, D.A.; Simone, N.L.; Hayes, S.B.; Woodward, W.A.; McCormick, B.; et al. NRG Oncology–Radiation Therapy Oncology Group Study 1014: 1-Year Toxicity Report from a Phase 2 Study of Repeat Breast-Preserving Surgery and 3-Dimensional Conformal Partial-Breast Reirradiation for In-Breast Recurrence. Int. J. Radiat. Oncol. Biol. Phys. 2017, 98, 1028–1035. [Google Scholar] [CrossRef]
- Forster, T.; Akbaba, S.; Schmitt, D.; Krug, D.; El Shafie, R.; Oelmann-Avendano, J.; Lindel, K.; König, L.; Arians, N.; Bernhardt, D.; et al. Second breast conserving therapy after ipsilateral breast tumor recurrence—A 10-year experience of re-irradiation. J. Contemp. Brachyther. 2019, 11, 312–319. [Google Scholar] [CrossRef]
- Hannoun-Levi, J.-M.; Resch, A.; Gal, J.; Kauer-Dorner, D.; Strnad, V.; Niehoff, P.; Loessl, K.; Kovács, G.; Van Limbergen, E.; Polgár, C. Accelerated partial breast irradiation with interstitial brachytherapy as second conservative treatment for ipsilateral breast tumour recurrence: Multicentric study of the GEC-ESTRO Breast Cancer Working Group. Radiother. Oncol. 2013, 108, 226–231. [Google Scholar] [CrossRef]
- Maulard, C.; Housset, M.; Brunei, P.; Delanian, S.; Taurelle, R.; Baillet, F. Use of Perioperative or Split-Course Interstitial Brachytherapy Techniques for Salvage Irradiation of Isolated Local Recurrences After Conservative Management of Breast Cancer. Am. J. Clin. Oncol. 1995, 18, 348–352. [Google Scholar] [CrossRef]
- Resch, A.; Fellner, C.; Mock, U.; Handl-Zeller, L.; Biber, E.; Seitz, W.; Pötter, R. Locally Recurrent Breast Cancer: Pulse Dose Rate Brachytherapy for Repeat Irradiation Following Lumpectomy—A Second Chance to Preserve the Breast. Radiology 2002, 225, 713–718. [Google Scholar] [CrossRef]
- Trombetta, M.; Hall, M.; Julian, T.B. Long-term followup of breast preservation by re-excision and balloon brachytherapy after ipsilateral breast tumor recurrence. Brachytherapy 2014, 13, 488–492. [Google Scholar] [CrossRef] [PubMed]
- Fattahi, S.; Ahmed, S.K.; Park, S.S.; Petersen, I.A.; Shumway, D.A.; Stish, B.J.; Yan, E.S.; Remmes, N.B.; Mutter, R.W.; Corbin, K.S. Reirradiation for Locoregional Recurrent Breast Cancer. Adv. Radiat. Oncol. 2021, 6, 100640. [Google Scholar] [CrossRef] [PubMed]
- Oldenborg, S.; Griesdoorn, V.; van Os, R.; Kusumanto, Y.H.; Oei, B.S.; Venselaar, J.L.; Zum Vorde Sive Vording, P.J.; Heymans, M.W.; Kolff, M.W.; Rasch, C.R.; et al. Reirradiation and hyperthermia for irresectable locoregional recurrent breast cancer in previously irradiated area: Size matters. Radiother. Oncol. 2015, 117, 223–228. [Google Scholar] [CrossRef] [PubMed]
- Barker, H.E.; Paget, J.T.E.; Khan, A.A.; Harrington, K.J. The tumour microenvironment after radiotherapy: Mechanisms of resistance and recurrence. Nat. Rev. Cancer 2015, 15, 409–425. [Google Scholar] [CrossRef]
- Kamble, D.; Mahajan, M.; Dhat, R.; Sitasawad, S. Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells. Cells 2021, 10, 83. [Google Scholar] [CrossRef]
- Bradley, J.A.; Dagan, R.; Ho, M.W.; Rutenberg, M.; Morris, C.G.; Li, Z.; Mendenhall, N.P. Initial Report of a Prospective Dosimetric and Clinical Feasibility Trial Demonstrates the Potential of Protons to Increase the Therapeutic Ratio in Breast Cancer Compared with Photons. Int. J. Radiat. Oncol. Biol. Phys. 2016, 95, 411–421. [Google Scholar] [CrossRef]
- De Rose, F.; Cozzi, L.; Meattini, I.; Fogliata, A.; Franceschini, D.; Franzese, C.; Tomatis, S.; Becherini, C.; Livi, L.; Scorsetti, M. The Potential Role of Intensity-modulated Proton Therapy in the Regional Nodal Irradiation of Breast Cancer: A Treatment Planning Study. Clin. Oncol. 2020, 32, 26–34. [Google Scholar] [CrossRef]
- Ranger, A.; Dunlop, A.; Hutchinson, K.; Convery, H.; Maclennan, M.K.; Chantler, H.; Twyman, N.; Rose, C.; McQuaid, D.; Amos, R.A.; et al. A Dosimetric Comparison of Breast Radiotherapy Techniques to Treat Locoregional Lymph Nodes Including the Internal Mammary Chain. Clin. Oncol. 2018, 30, 346–353. [Google Scholar] [CrossRef] [PubMed]
- Simone, C.B., 2nd; Plastaras, J.P.; Jabbour, S.K.; Lee, A.; Lee, N.Y.; Choi, J.I.; Frank, S.J.; Chang, J.Y.; Bradley, J. Proton Reirradiation: Expert Recommendations for Reducing Toxicities and Offering New Chances of Cure in Patients with Challenging Recurrence Malignancies. Semin. Radiat. Oncol. 2020, 30, 253–261. [Google Scholar] [CrossRef] [PubMed]
- Verma, V.; Rwigema, J.M.; Malyapa, R.S.; Regine, W.F.; Simone, C.B., 2nd. Systematic assessment of clinical outcomes and toxicities of proton radiotherapy for reirradiation. Radiother. Oncol. 2017, 125, 21–30. [Google Scholar] [CrossRef]
- Braunstein, L.Z.; Cahlon, O. Potential Morbidity Reduction with Proton Radiation Therapy for Breast Cancer. Semin. Radiat. Oncol. 2018, 28, 138–149. [Google Scholar] [CrossRef] [PubMed]
- Brownlee, Z.; Garg, R.; Listo, M.; Zavitsanos, P.; Wazer, D.E.; Huber, K.E. Late complications of radiation therapy for breast cancer: Evolution in techniques and risk over time. Gland. Surg. 2018, 7, 371–378. [Google Scholar] [CrossRef]
- White, J.; Joiner, M.C. Toxicity from Radiation in Breast Cancer. In Radiation Toxicity: A Practical Guide; Small, W., Woloschak, G.E., Eds.; Springer: Boston, MA, USA, 2006; pp. 65–109. [Google Scholar]
- Darby, S.C.; Ewertz, M.; McGale, P.; Bennet, A.M.; Blom-Goldman, U.; Brønnum, D.; Correa, C.; Cutter, D.; Gagliardi, G.; Gigante, B.; et al. Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer. N. Engl. J. Med. 2013, 368, 987–998. [Google Scholar] [CrossRef]
- van den Bogaard, V.A.; Ta, B.D.; Van Der Schaaf, A.; Bouma, A.B.; Middag, A.M.; Bantema-Joppe, E.J.; Van Dijk, L.V.; Van Dijk-Peters, F.B.; Marteijn, L.A.; De Bock, G.H.; et al. Validation and Modification of a Prediction Model for Acute Cardiac Events in Patients with Breast Cancer Treated with Radiotherapy Based on Three-Dimensional Dose Distributions to Cardiac Substructures. J. Clin. Oncol. 2017, 35, 1171–1178. [Google Scholar] [CrossRef]
- Taylor, C.; McGale, P.; Bronnum, D.; Correa, C.; Cutter, D.; Duane, F.K.; Gigante, B.; Jensen, M.B.; Lorenzen, E.; Rahimi, K.; et al. Cardiac Structure Injury After Radiotherapy for Breast Cancer: Cross-Sectional Study with Individual Patient Data. J. Clin. Oncol. 2018, 36, 2288–2296. [Google Scholar] [CrossRef]
- Taylor, C.; Correa, C.; Duane, F.K.; Aznar, M.C.; Anderson, S.J.; Bergh, J.; Dodwell, D.; Ewertz, M.; Gray, R.; Jagsi, R.; et al. Estimating the Risks of Breast Cancer Radiotherapy: Evidence from Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials. J. Clin. Oncol. 2017, 35, 1641–1649. [Google Scholar] [CrossRef]
- De Crevoisier, R.; Bourhis, J.; Domenge, C.; Wibault, P.; Koscielny, S.; Lusinchi, A.; Mamelle, G.; Janot, F.; Julieron, M.; Leridant, A.M.; et al. Full-dose reirradiation for unresectable head and neck carcinoma: Experience at the Gustave-Roussy Institute in a series of 169 patients. J. Clin. Oncol. 1998, 16, 3556–3562. [Google Scholar] [CrossRef]
- Xu, A.J.; DeSelm, C.J.; Ho, A.Y.; Gillespie, E.F.; Braunstein, L.Z.; Khan, A.J.; McCormick, B.; Powell, S.N.; Cahlon, O. Overall Survival of Breast Cancer Patients with Locoregional Failures Involving Internal Mammary Nodes. Adv. Radiat. Oncol. 2019, 4, 447–452. [Google Scholar] [CrossRef] [PubMed]
- Moskvin, V.P.; Estabrook, N.C.; Cheng, C.-W.; Das, I.J.; Johnstone, P.A.S. Effect of Scanning Beam for Superficial Dose in Proton Therapy. Technol. Cancer Res. Treat. 2014, 14, 643–652. [Google Scholar] [CrossRef] [PubMed]
- Cuaron, J.J.; Cheng, C.; Joseph, H.; McNeeley, S.; Hug, E.B.; Chon, B.H.; Tsai, H.K.; Powell, S.N.; Cahlon, O. Dosimetric Comparison of Skin Surface Dose in Patients Undergoing Proton and Photon Radiation Therapy for Breast Cancer. Int. J. Radiat. Oncol. Biol. Phys. 2014, 90, S914. [Google Scholar] [CrossRef]
- Newhauser, W.D.; Zhang, R. The physics of proton therapy. Phys. Med. Biol. 2015, 60, R155. [Google Scholar] [CrossRef] [PubMed]
- Patyal, B. Dosimetry aspects of proton therapy. Technol. Cancer Res. Treat. 2007, 6, 17–23. [Google Scholar] [CrossRef] [PubMed]
- Mutter, R.W.; Choi, J.I.; Jimenez, R.B.; Kirova, Y.M.; Fagundes, M.; Haffty, B.G.; Amos, R.A.; Bradley, J.A.; Chen, P.Y.; Ding, X.; et al. Proton Therapy for Breast Cancer: A Consensus Statement from the Particle Therapy Cooperative Group Breast Cancer Subcommittee. Int. J. Radiat. Oncol. Biol. Phys. 2021, 111, 337–359. [Google Scholar] [CrossRef]
- Fagundes, M.; Hug, E.B.; Pankuch, M.; Fang, C.; McNeeley, S.; Mao, L.; Lavilla, M.; Schmidt, S.L.; Ward, C.; Cahlon, O.; et al. Proton Therapy for Local-regionally Advanced Breast Cancer Maximizes Cardiac Sparing. Int. J. Part Ther. 2015, 1, 827–844. [Google Scholar] [CrossRef]
- Lin, L.L.; Vennarini, S.; Dimofte, A.; Ravanelli, D.; Shillington, K.; Batra, S.; Tochner, Z.; Both, S.; Freedman, G. Proton beam versus photon beam dose to the heart and left anterior descending artery for left-sided breast cancer. Acta Oncol. 2015, 54, 1032–1039. [Google Scholar] [CrossRef]
- Loap, P.; Tkatchenko, N.; Goudjil, F.; Ribeiro, M.; Baron, B.; Fourquet, A.; Kirova, Y. Cardiac substructure exposure in breast radiotherapy: A comparison between intensity modulated proton therapy and volumetric modulated arc therapy. Acta Oncol. 2021, 60, 1038–1044. [Google Scholar] [CrossRef]
- Mast, M.E.; Vredeveld, E.J.; Credoe, H.M.; van Egmond, J.; Heijenbrok, M.W.; Hug, E.B.; Kalk, P.; van Kempen-Harteveld, L.M.L.; Korevaar, E.W.; van der Laan, H.P.; et al. Whole breast proton irradiation for maximal reduction of heart dose in breast cancer patients. Breast Cancer Res. Treat. 2014, 148, 33–39. [Google Scholar] [CrossRef]
- Milligan, M.G.; Zieminski, S.; Johnson, A.; Depauw, N.; Rosado, N.; Specht, M.C.; Liao, E.C.; Jimenez, R.B. Target coverage and cardiopulmonary sparing with the updated ESTRO-ACROP contouring guidelines for postmastectomy radiation therapy after breast reconstruction: A treatment planning study using VMAT and proton PBS techniques. Acta Oncol. 2021, 60, 1440–1451. [Google Scholar] [CrossRef]
- Nangia, S.; Burela, N.; Noufal, M.P.; Patro, K.; Wakde, M.G.; Sharma, D.S. Proton therapy for reducing heart and cardiac substructure doses in Indian breast cancer patients. Radiat. Oncol. J. 2023, 41, 69–80. [Google Scholar] [CrossRef] [PubMed]
- Sun, T.; Lin, X.; Tong, Y.; Liu, X.; Pan, L.; Tao, C.; Duan, J.; Yin, Y. Heart and Cardiac Substructure Dose Sparing in Synchronous Bilateral Breast Radiotherapy: A Dosimetric Study of Proton and Photon Radiation Therapy. Front. Oncol. 2020, 9, 1456. [Google Scholar] [CrossRef]
- Ares, C.; Khan, S.; MacArtain, A.M.; Heuberger, J.; Goitein, G.; Gruber, G.; Lutters, G.; Hug, E.B.; Bodis, S.; Lomax, A.J. Postoperative Proton Radiotherapy for Localized and Locoregional Breast Cancer: Potential for Clinically Relevant Improvements? Int. J. Radiat. Oncol. Biol. Phys. 2010, 76, 685–697. [Google Scholar] [CrossRef] [PubMed]
- Mondal, D.; Jhawar, S.R.; Millevoi, R.; Haffty, B.G.; Parikh, R.R. Proton versus Photon Breath-Hold Radiation for Left-Sided Breast Cancer after Breast-Conserving Surgery: A Dosimetric Comparison. Int. J. Part Ther. 2020, 7, 24–33. [Google Scholar] [CrossRef]
- Patel, S.A.; Lu, H.-M.; Nyamwanda, J.A.; Jimenez, R.B.; Taghian, A.G.; MacDonald, S.M.; Depauw, N. Postmastectomy radiation therapy technique and cardiopulmonary sparing: A dosimetric comparative analysis between photons and protons with free breathing versus deep inspiration breath hold. Pract. Radiat. Oncol. 2017, 7, e377–e384. [Google Scholar] [CrossRef] [PubMed]
- Raptis, A.; Ödén, J.; Ardenfors, O.; Flejmer, A.M.; Toma-Dasu, I.; Dasu, A. Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties. Phys. Med. 2020, 76, 1–6. [Google Scholar] [CrossRef]
- Brooks, E.D.; Mailhot Vega, R.B.; Vivers, E.; Burchianti, T.; Liang, X.; Spiguel, L.R.; Jasra, B.; Mendenhall, N.P.; Oladeru, O.T.; Bradley, J.A. Proton Therapy for Bilateral Breast Cancer Maximizes Normal-Tissue Sparing. Int. J. Part. Ther. 2023, 9, 290–301. [Google Scholar] [CrossRef]
- Choi, J.I.; McCormick, B.; Park, P.; Millar, M.; Walker, K.; Tung, C.C.; Huang, S.; Florio, P.; Chen, C.-C.; Lozano, A.; et al. Comparative Evaluation of Proton Therapy and Volumetric Modulated Arc Therapy for Brachial Plexus Sparing in the Comprehensive Reirradiation of High-Risk Recurrent Breast Cancer. Adv. Radiat. Oncol. 2023, 101355. [Google Scholar] [CrossRef]
- Thorpe, C.S.; Niska, J.R.; Girardo, M.E.; Kosiorek, H.E.; McGee, L.A.; Hartsell, W.F.; Larson, G.L.; Tsai, H.K.; Rossi, C.J.; Rosen, L.R.; et al. Proton beam therapy reirradiation for breast cancer: Multi-institutional prospective PCG registry analysis. Breast J. 2019, 25, 1160–1170. [Google Scholar] [CrossRef]
- Gabani, P.; Patel, H.; Thomas, M.A.; Bottani, B.; Goddu, S.M.; Straube, W.; Margenthaler, J.A.; Ochoa, L.; Bradley, J.D.; Zoberi, I. Clinical outcomes and toxicity of proton beam radiation therapy for re-irradiation of locally recurrent breast cancer. Clin. Transl. Radiat. Oncol. 2019, 19, 116–122. [Google Scholar] [CrossRef]
- Wahl, A.O.; Rademaker, A.; Kiel, K.D.; Jones, E.L.; Marks, L.B.; Croog, V.; McCormick, B.M.; Hirsch, A.; Karkar, A.; Motwani, S.B.; et al. Multi-Institutional Review of Repeat Irradiation of Chest Wall and Breast for Recurrent Breast Cancer. Int. J. Radiat. Oncol. Biol. Phys. 2008, 70, 477–484. [Google Scholar] [CrossRef]
- LaRiviere, M.J.; Dreyfuss, A.; Taunk, N.K.; Freedman, G.M. Proton Reirradiation for Locoregionally Recurrent Breast Cancer. Adv. Radiat. Oncol. 2021, 6, 100710. [Google Scholar] [CrossRef]
- Jimenez, R.B.; Hickey, S.; DePauw, N.; Yeap, B.Y.; Batin, E.; Gadd, M.A.; Specht, M.; Isakoff, S.J.; Smith, B.L.; Liao, E.C.; et al. Phase II Study of Proton Beam Radiation Therapy for Patients with Breast Cancer Requiring Regional Nodal Irradiation. J. Clin. Oncol. 2019, 37, 2778–2785. [Google Scholar] [CrossRef]
- Choi, J.I.; Khan, A.J.; Powell, S.N.; McCormick, B.; Lozano, A.J.; Del Rosario, G.; Mamary, J.; Liu, H.; Fox, P.; Gillespie, E.; et al. Proton reirradiation for recurrent or new primary breast cancer in the setting of prior breast irradiation. Radiother. Oncol. 2021, 165, 142–151. [Google Scholar] [CrossRef] [PubMed]
- Sayan, M.; Vergalasova, I.; Jan, I.; Kumar, S.; Chan, N.; Haffty, B.G.; Ohri, N. Toxicities and Locoregional Control After External Beam Chest Wall and/or Regional Lymph Node Re-irradiation for Recurrent Breast Cancer. Anticancer Res. 2022, 42, 93–96. [Google Scholar] [CrossRef] [PubMed]
- Paganetti, H.; Blakely, E.; Carabe-Fernandez, A.; Carlson, D.J.; Das, I.J.; Dong, L.; Grosshans, D.; Held, K.D.; Mohan, R.; Moiseenko, V.; et al. Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Med. Phys. 2019, 46, e53–e78. [Google Scholar] [CrossRef] [PubMed]
- Underwood, T.S.A.; McNamara, A.L.; Appelt, A.; Haviland, J.S.; Sorensen, B.S.; Troost, E.G.C. A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE). Radiother. Oncol. 2022, 175, 79–92. [Google Scholar] [CrossRef] [PubMed]
- Jones, B. Why RBE must be a variable and not a constant in proton therapy. Br. J. Radiol. 2016, 89, 20160116. [Google Scholar] [CrossRef] [PubMed]
- Corbin, K.S.; Mutter, R.W. Proton therapy for breast cancer: Progress & pitfalls. Breast Cancer Manag. 2018, 7, BMT06. [Google Scholar] [CrossRef]
- Jones, B.; Hopewell, J.W. Spinal cord re-treatments using photon and proton based radiotherapy: LQ-derived tolerance doses. Phys. Med. 2019, 64, 304–310. [Google Scholar] [CrossRef] [PubMed]
- Mutter, R.W.; Jethwa, K.R.; Wan Chan Tseung, H.S.; Wick, S.M.; Kahila, M.M.H.; Viehman, J.K.; Shumway, D.A.; Corbin, K.S.; Park, S.S.; Remmes, N.B.; et al. Incorporation of Biologic Response Variance Modeling into the Clinic: Limiting Risk of Brachial Plexopathy and Other Late Effects of Breast Cancer Proton Beam Therapy. Pract. Radiat. Oncol. 2020, 10, e71–e81. [Google Scholar] [CrossRef] [PubMed]
- Underwood, T.S.A.; Grassberger, C.; Bass, R.; MacDonald, S.M.; Meyersohn, N.M.; Yeap, B.Y.; Jimenez, R.B.; Paganetti, H. Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated with a Proton RBE Exceeding 1.1. Int. J. Radiat. Oncol. Biol. Phys. 2018, 101, 809–819. [Google Scholar] [CrossRef] [PubMed]
- Wang, C.C.; McNamara, A.L.; Shin, J.; Schuemann, J.; Grassberger, C.; Taghian, A.G.; Jimenez, R.B.; MacDonald, S.M.; Paganetti, H. End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer. Int. J. Radiat. Oncol. Biol. Phys. 2020, 107, 449–454. [Google Scholar] [CrossRef] [PubMed]
- Bradley, J.A.; Liang, X.; Mailhot Vega, R.B.; Liu, C.; Brooks, E.D.; Burchianti, T.; Viviers, E.; Dagan, R.; Oladeru, O.T.; Morris, C.G.; et al. Incidence of Rib Fracture following Treatment with Proton Therapy for Breast Cancer. Int. J. Part. Ther. 2023, 9, 269–278. [Google Scholar] [CrossRef]
- McMahon, S.J.; Paganetti, H.; Prise, K.M. LET-weighted doses effectively reduce biological variability in proton radiotherapy planning. Phys. Med. Biol. 2018, 63, 225009. [Google Scholar] [CrossRef]
- Kowalchuk, R.O.; Corbin, K.S.; Jimenez, R.B. Particle Therapy for Breast Cancer. Cancers 2022, 14, 1066. [Google Scholar] [CrossRef]
- Batin, E.; Depauw, N.; MacDonald, S.; Lu, H.-M. Can surface imaging improve the patient setup for proton postmastectomy chest wall irradiation? Pract. Radiat. Oncol. 2016, 6, e235–e241. [Google Scholar] [CrossRef]
- Wiant, D.B.; Wentworth, S.; Maurer, J.M.; Vanderstraeten, C.L.; Terrell, J.A.; Sintay, B.J. Surface imaging-based analysis of intrafraction motion for breast radiotherapy patients. J. Appl Clin. Med. Phys. 2014, 15, 4957. [Google Scholar] [CrossRef]
- Al-Hallaq, H.A.; Cervino, L.; Gutierrez, A.N.; Havnen-Smith, A.; Higgins, S.A.; Kugele, M.; Padilla, L.; Pawlicki, T.; Remmes, N.; Smith, K.; et al. AAPM task group report 302: Surface-guided radiotherapy. Med. Phys. 2022, 49, e82–e112. [Google Scholar] [CrossRef]
- Gao, R.W.; Mullikin, T.C.; Aziz, K.A.; Afzal, A.; Smith, N.L.; Routman, D.M.; Gergelis, K.R.; Harmsen, W.S.; Remmes, N.B.; Tseung, H.S.W.C.; et al. Postmastectomy Intensity Modulated Proton Therapy: 5-Year Oncologic and Patient-Reported Outcomes. Int. J. Radiat. Oncol. Biol. Phys 2023, 117, 846–856. [Google Scholar] [CrossRef]
- Depauw, N.; Batin, E.; Daartz, J.; Rosenfeld, A.; Adams, J.; Kooy, H.; MacDonald, S.; Lu, H.-M. A Novel Approach to Postmastectomy Radiation Therapy Using Scanned Proton Beams. Int. J. Radiat. Oncol. Biol. Phys. 2015, 91, 427–434. [Google Scholar] [CrossRef]
- Mutter, R.W.; Remmes, N.B.; Kahila, M.M.H.; Hoeft, K.A.; Pafundi, D.H.; Zhang, Y.; Corbin, K.S.; Park, S.S.; Yan, E.S.; Lemaine, V.; et al. Initial clinical experience of postmastectomy intensity modulated proton therapy in patients with breast expanders with metallic ports. Pract. Radiat. Oncol. 2017, 7, e243–e252. [Google Scholar] [CrossRef]
- DeCesaris, C.M.; Mossahebi, S.; Jatczak, J.; Rao, A.D.; Zhu, M.; Mishra, M.V.; Nichols, E. Outcomes of and treatment planning considerations for a hybrid technique delivering proton pencil-beam scanning radiation to women with metal-containing tissue expanders undergoing post-mastectomy radiation. Radiother. Oncol. 2021, 164, 289–298. [Google Scholar] [CrossRef]
- Wapnir, I.L.; Price, K.N.; Anderson, S.J.; Robidoux, A.; Martín, M.; Nortier, J.W.R.; Paterson, A.H.G.; Rimawi, M.F.; Láng, I.; Baena-Cañada, J.M.; et al. Efficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial. J. Clin. Oncol. 2018, 36, 1073–1079. [Google Scholar] [CrossRef]
- Grambozov, B.; Stana, M.; Kaiser, B.; Karner, J.; Gerum, S.; Ruznic, E.; Zellinger, B.; Moosbrugger, R.; Studnicka, M.; Fastner, G.; et al. High Dose Thoracic Re-Irradiation and Chemo-Immunotherapy for Centrally Recurrent NSCLC. Cancers 2022, 14, 573. [Google Scholar] [CrossRef]
- Kreinbrink, P.J.; Lewis, L.M.; Redmond, K.P.; Takiar, V. Reirradiation of Recurrent and Second Primary Cancers of the Head and Neck: A Review of the Contemporary Evidence. Curr. Treat. Options Oncol. 2022, 23, 295–310. [Google Scholar] [CrossRef]
- Xu, X.; Wang, Z.; Jiang, S.; Shang, Y.; Wu, Y. Evaluating the optimal re-irradiation dose for locally recurrent esophageal squamous cell carcinoma after definitive radiotherapy. Radiat. Oncol. 2019, 14, 191. [Google Scholar] [CrossRef]
- Johansson, S.; Svensson, H.; Denekamp, J. Dose response and latency for radiation-induced fibrosis, edema, and neuropathy in breast cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 2002, 52, 1207–1219. [Google Scholar] [CrossRef]
- Jones, B.; Grant, W. Retreatment of Central Nervous System Tumours. Clin. Oncol. 2014, 26, 407–418. [Google Scholar] [CrossRef]
- Nishimura, Y. Rationale for chemoradiotherapy. Int. J. Clin. Oncol. 2004, 9, 414–420. [Google Scholar] [CrossRef]
- Janot, F.; de Raucourt, D.; Benhamou, E.; Ferron, C.; Dolivet, G.; Bensadoun, R.-J.; Hamoir, M.; Géry, B.; Julieron, M.; Castaing, M.; et al. Randomized Trial of Postoperative Reirradiation Combined with Chemotherapy After Salvage Surgery Compared with Salvage Surgery Alone in Head and Neck Carcinoma. J. Clin. Oncol. 2008, 26, 5518–5523. [Google Scholar] [CrossRef]
- Chang, J.Y.; Verma, V.; Li, M.; Zhang, W.; Komaki, R.; Lu, C.; Allen, P.K.; Liao, Z.; Welsh, J.; Lin, S.H.; et al. Proton Beam Radiotherapy and Concurrent Chemotherapy for Unresectable Stage III Non–Small Cell Lung Cancer: Final Results of a Phase 2 Study. JAMA Oncol. 2017, 3, e172032. [Google Scholar] [CrossRef]
- Uezono, H.; Indelicato, D.J.; Rotondo, R.L.; Sandler, E.S.; Katzenstein, H.M.; Dagan, R.; Mendenhall, W.M.; Mailhot Vega, R.; Brennan, B.M.; Bradley, J.A. Proton therapy following induction chemotherapy for pediatric and adolescent nasopharyngeal carcinoma. Pediatr. Blood Cancer 2019, 66, e27990. [Google Scholar] [CrossRef]
- Lee Jr, H.J.; Zeng, J.; Rengan, R. Proton beam therapy and immunotherapy: An emerging partnership for immune activation in non-small cell lung cancer. Transl. Lung. Cancer Res. 2018, 7, 180–188. [Google Scholar] [CrossRef]
- D’Andrea, M.A.; Reddy, G.K. Systemic Immunostimulatory Effects of Radiation Therapy Improves the Outcomes of Patients with Advanced NSCLC Receiving Immunotherapy. Am. J. Clin. Oncol. 2020, 43, 218–228. [Google Scholar] [CrossRef]
- Mailhot Vega, R.B.; Ishaq, O.; Raldow, A.; Perez, C.A.; Jimenez, R.; Scherrer-Crosbie, M.; Bussiere, M.; Taghian, A.; Sher, D.J.; MacDonald, S.M. Establishing Cost-Effective Allocation of Proton Therapy for Breast Irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2016, 95, 11–18. [Google Scholar] [CrossRef]
Study | Study Type | Population | Key Results |
---|---|---|---|
Proton Collaborative Group (PCG) Thorpe et al. (2019) [51] | Prospective | 50 patients receiving proton reRT (24% PBS-PBT, 52% US-PBT, 24% unspecified) | 12-month LRFS: 93.0% 12-month OS: 97.0% Acute grade 3 toxicities: 10.0% Late grade 3 toxicities: 8.0% |
Washington University School of Medicine Gabani et al. (2019) [52] | Retrospective | 16 patients receiving PS-PBT reRT | 18-month LRFS: 100% 18-month DMFS: 93.3% 18-month OS: 88.9% Acute grade 3–4 skin toxicities: 5 patients (31.2%) Late grade 3–4 fibrosis: 3 patients (18.8%) |
Mayo Clinic Fattahi et al. (2020) [15] | Retrospective | 72 patients undergoing reRT, 20 (28%) of whom received IMPT | 2-year LRFS: 74.6% 2-year OS: 65.6% Grade 3 adverse events: 13% |
University of Pennsylvania LaRiviere et al. (2020) [54] | Retrospective | 27 patients receiving proton reRT (29.0% DS-PBT, 66.7% PBS-PBT, 3.7% combined DS-PBT and PBS-PBT) | 12-month LRFS: 78.5% 12-month RFS: 62.4% 12-month OS: 78.5% Acute grade 3 radiation dermatitis: 2 patients (7.4%) Acute grade 3 breast pain: 2 patients (7.4%) Late grade 3 dermatitis: 1 patient (3.7%) Late grade 3 breast pain: 1 patient (3.7%) Late grade 4 dermatitis: 1 patient (3.7%) |
New York Proton Center/Memorial Sloan Kettering Cancer Center Choi et al. (2021) [56] | Retrospective | 46 patients receiving proton reRT (70% US-PBT, 30% PBS-PBT) | 2-year DMFS: 92.0% 3-year DMFS: 60.0% 2-year OS: 93.6% 3-year OS: 88.1% Acute grade 3 events: 30.4% Late grade 3 events: 8.7% |
Rutgers Cancer Institute of New Jersey Sayan et al. (2022) [57] | Retrospective | 15 patients undergoing reRT, 12 (80%) of which received PBT (unspecified type) | Locoregional recurrence: 27% Distant metastasis after 14 months: 33% Any grade 3 toxicity: 13% |
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Chakraborty, M.A.; Khan, A.J.; Cahlon, O.; Xu, A.J.; Braunstein, L.Z.; Powell, S.N.; Choi, J.I. Proton Reirradiation for High-Risk Recurrent or New Primary Breast Cancer. Cancers 2023, 15, 5722. https://doi.org/10.3390/cancers15245722
Chakraborty MA, Khan AJ, Cahlon O, Xu AJ, Braunstein LZ, Powell SN, Choi JI. Proton Reirradiation for High-Risk Recurrent or New Primary Breast Cancer. Cancers. 2023; 15(24):5722. https://doi.org/10.3390/cancers15245722
Chicago/Turabian StyleChakraborty, Molly A., Atif J. Khan, Oren Cahlon, Amy J. Xu, Lior Z. Braunstein, Simon N. Powell, and J. Isabelle Choi. 2023. "Proton Reirradiation for High-Risk Recurrent or New Primary Breast Cancer" Cancers 15, no. 24: 5722. https://doi.org/10.3390/cancers15245722