Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Radiochemistry of 18F-TBD
2.2. Dynamic PET Imaging with 18F-TBD
2.3. PET Imaging with [18F]4FN and [18F]FDG
2.4. Quantitation of Liver Fat and Liver Volume Using MR
2.5. Measurement of Liver Density Using CT
2.6. PTEN Deletion Mouse Model
3. Results
3.1. Liver PTEN Model—Males
3.2. Liver PTEN Model—Female Cohort
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Engel, B.J.; Paolillo, V.; Uddin, M.N.; Gonzales, K.A.; McGinnis, K.M.; Sutton, M.N.; Patnana, M.; Grindel, B.J.; Gores, G.J.; Piwnica-Worms, D.; et al. Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging. Cancers 2023, 15, 3787. https://doi.org/10.3390/cancers15153787
Engel BJ, Paolillo V, Uddin MN, Gonzales KA, McGinnis KM, Sutton MN, Patnana M, Grindel BJ, Gores GJ, Piwnica-Worms D, et al. Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging. Cancers. 2023; 15(15):3787. https://doi.org/10.3390/cancers15153787
Chicago/Turabian StyleEngel, Brian J., Vincenzo Paolillo, Md. Nasir Uddin, Kristyn A. Gonzales, Kathryn M. McGinnis, Margie N. Sutton, Madhavi Patnana, Brian J. Grindel, Gregory J. Gores, David Piwnica-Worms, and et al. 2023. "Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging" Cancers 15, no. 15: 3787. https://doi.org/10.3390/cancers15153787