The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review
Abstract
:Simple Summary
Abstract
1. Introduction
2. Four Crucial Points
3. Some Points of Clarification
4. Open Questions
5. Conclusions
6. Future Directions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Authors | Study Type | Numbers | Results |
---|---|---|---|
Dove-Edwin I et al. [23] | Prospective observational 2005 | 1678 patiens | Interval colonoscopy on the basis of family history |
Engel C et al. [30] | Prospective coohrt 2010 | 1126 patients | Annual colonoscopy is recommended |
Lindberg LJ et al. [31] | Prospective observational 2017 | 13,444 surveillance sessions | Elevated cancer risk despite biannual surveillance |
Engel C et al. [25] | Population 3 countries 2018 | 2747 patients | Similar cancer risk at different intervals of surveillance colonscopy |
Ahadova A et al. [32] | Prospective 2021 | 28 incident cancer 7 prevalent cancer | Timing of colonoscopy does not modify cancer risk |
Bultman SJ [33] | Retrospective 2021 | 325 removed lesions | Malignant-transformation interval is similar in all segments of the colon |
Authors | Study Type | Patients Enrolled | Results |
---|---|---|---|
Møller P et al. [11] | Prospective observational 2017 | 6350 | Cancer risk related to specific gene mutation and gender of individuals with LS |
Dominguez-Valentin M, et al. [24] | Prospective observational 2020 | 6350 | Cancer risk related to specific gene mutation, gender, and age of individuals with LS |
Kastrinos F et al. [36] | Simulation model 2021 | 6350 | CRC surveillance intervals on the basis of the type of specific gene mutation |
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D’Angelo, V.; Rega, D.; Marone, P.; Di Girolamo, E.; Civiletti, C.; Tatangelo, F.; Duraturo, F.; De Rosa, M.; de Bellis, M.; Delrio, P. The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review. Cancers 2023, 15, 3780. https://doi.org/10.3390/cancers15153780
D’Angelo V, Rega D, Marone P, Di Girolamo E, Civiletti C, Tatangelo F, Duraturo F, De Rosa M, de Bellis M, Delrio P. The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review. Cancers. 2023; 15(15):3780. https://doi.org/10.3390/cancers15153780
Chicago/Turabian StyleD’Angelo, Valentina, Daniela Rega, Pietro Marone, Elena Di Girolamo, Corrado Civiletti, Fabiana Tatangelo, Francesca Duraturo, Marina De Rosa, Mario de Bellis, and Paolo Delrio. 2023. "The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review" Cancers 15, no. 15: 3780. https://doi.org/10.3390/cancers15153780