Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions
Abstract
:Simple Summary
Abstract
1. Introduction
2. Neutrophils
2.1. Features and Functions
2.2. Metabolism
2.3. Low-Density Neutrophils
3. Tumor-Associated Neutrophils (TANs)
3.1. Recruitment of Neutrophils in the TME
3.2. Features of Tumor-Associated Neutrophils
3.2.1. Pro-Tumor Activity
3.2.2. Anti-Tumor Activity
3.2.3. Single-Cell Studies Resolving Neutrophil Heterogeneity
4. How the TME Can Influence Neutrophil Biology
5. How Neutrophils/TANs Can Influence Tumor Prognosis
6. How Neutrophils/TANs Can Influence ICI Therapy
7. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Gibellini, L.; Borella, R.; Santacroce, E.; Serattini, E.; Boraldi, F.; Quaglino, D.; Aramini, B.; De Biasi, S.; Cossarizza, A. Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions. Cancers 2023, 15, 3327. https://doi.org/10.3390/cancers15133327
Gibellini L, Borella R, Santacroce E, Serattini E, Boraldi F, Quaglino D, Aramini B, De Biasi S, Cossarizza A. Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions. Cancers. 2023; 15(13):3327. https://doi.org/10.3390/cancers15133327
Chicago/Turabian StyleGibellini, Lara, Rebecca Borella, Elena Santacroce, Eugenia Serattini, Federica Boraldi, Daniela Quaglino, Beatrice Aramini, Sara De Biasi, and Andrea Cossarizza. 2023. "Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions" Cancers 15, no. 13: 3327. https://doi.org/10.3390/cancers15133327