Influence of Sociodemographic Determinants on the Hodgkin Lymphoma Baseline Characteristics in Long Survivors Patients Enrolled in the Prospective Phase 3 Trial AHL2011
Abstract
:Simple Summary
Abstract
1. Introduction
2. Material and Methods
2.1. Patients and Study Design
2.2. Socio-Demographical Data
2.3. PET/CT Acquisition and Analysis
2.4. Statistics
3. Results
3.1. Patients
3.2. Analyses of Sociodemographic Characteristics
3.3. Relationships between Sociodemographic Features and Disease Characteristics
3.4. Relationships between Sociodemographic Features and PET Responses
3.5. Relationships of Sociodemographic Features and Outcome of These Long Survivor Patients
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
List of Presentations
References
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Patients’ Characteristics | AHL2011 Whole Cohort | Completed Survey | ZIP Code Available | ||
---|---|---|---|---|---|
N = 823 | N = 232 | Test | N = 163 | Test | |
Median age. years (range) | 30 (16–60) | 32 (16–60) | Wilcoxon p = 0.002 | 32 (17–59) | Wilcoxon p = 0.018 |
Male. No. (%) | 516 (62.7%) | 141 (60.8%) | Chi-2 p = 0.475 | 100 (61.3%) | Chi-2 p = 0.691 |
ECOG. No. (%) | Chi-2 p = 0.766 | Chi-2 p = 0.839 | |||
0 | 396 (48.4%) | 112 (48.5%) | 76 (46.9%) | ||
1 | 365 (44.6%) | 105 (45.5%) | 73 (45.1%) | ||
2 | 58 (7.1%) | 14 (6.1%) | 13 (8.0%) | ||
B symptoms. No. (%) | 263 (32.0%) | 66 (28.4%) | Chi-2 p = 0.176 | 48 (29.4%) | Chi-2 p = 0.443 |
Ann Arbor stage. No. (%) | Chi-2 p = 0.139 | Chi-2 p = 0.092 | |||
I or II | 98 (11.9%) | 36 (15.5%) | 28 (17.2%) | ||
III | 229 (27.8%) | 60 (25.9%) | 43 (26.4%) | ||
IV | 496 (60.3%) | 136 (58.6%) | 92 (56.4%) | ||
Stade IIB | 87 (10.6%) | 32 (13.8%) | Chi-2 p = 0.060 | 26 (16%) | Chi-2 p = 0.013 |
Bulky Mass. No. (%). cm | Chi-2 p = 0.695 | ||||
≤10 | 462 (62.5%) | 138 (63.9%) | Chi-2 p = 0.62 | 99 (63.9%) | |
>10 | 277 (37.5%) | 78 (36.1%) | 56 (36.1%) | ||
IPS group. No. (%) | Chi-2 p = 0.559 | Chi-2 p = 0.409 | |||
0–2 | 343 (41.9%) | 101 (43.5%) | 73 (44.8%) | ||
≥3 | 475 (58.1%) | 131 (56.5%) | 90 (55.2%) | ||
PET2 central review. No. (%) | Chi-2 p = 0.121 | Chi-2 p = 0.162 | |||
Positive | 100 (12.6%) | 22 (9.7%) | 15 (9.3%) | ||
Negative | 695 (87.4%) | 205 (90.3%) | 146 (90.7%) | ||
PET4 central review. No. (%) | Chi-2 p = 0.932 | ||||
Positive | 43 (5.7%) | 11 (5.1%) | Chi-2 p = 0.653 | 9 (5.8%) | |
Negative | 716 (94.3%) | 206 (94.9%) | 146 (94.2%) | ||
TMTV0 class | Chi-2 p = 0.994 | ||||
< 220 cm3 | 386 (52.2%) | 118 (54.6%) | Chi-2 p = 0.402 | 81 (52.3%) | |
≥ 220 cm3 | 353 (47.8%) | 98 (45.4%) | 74 (47.7%) |
Frequence N(%) | PFS 5 Years | |
---|---|---|
Marital status | ||
Isolated | 143 (61.9%) | 92 % |
Non-isolated | 88 (38.1%) | 86 % |
Living area | ||
Rural | 71 (31.1%) | 90.1% |
City | 157 (68.9%) | 87.3% |
Diploma | ||
High school graduation or below | 131 (58.0%) | 88.5% |
Above high school graduation | 95 (42.0%) | 88.4% |
Socio-professional categories | ||
Farmers/artisan/workers | 75 (33.3%) | 90.7% |
Executives/employees/student | 150 (66.7%) | 87.3% |
Professional context | ||
Active | 163 (71.2%) | 89.4% |
Non active | 66 (28.8%) | 87.7% |
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Chevreux, S.; de Barros, S.; Laurent, C.; Durand, A.; Delpierre, C.; Robert, P.; Joubert, C.; Griolet, S.; Kanoun, S.; Bastie, J.-N.; et al. Influence of Sociodemographic Determinants on the Hodgkin Lymphoma Baseline Characteristics in Long Survivors Patients Enrolled in the Prospective Phase 3 Trial AHL2011. Cancers 2023, 15, 53. https://doi.org/10.3390/cancers15010053
Chevreux S, de Barros S, Laurent C, Durand A, Delpierre C, Robert P, Joubert C, Griolet S, Kanoun S, Bastie J-N, et al. Influence of Sociodemographic Determinants on the Hodgkin Lymphoma Baseline Characteristics in Long Survivors Patients Enrolled in the Prospective Phase 3 Trial AHL2011. Cancers. 2023; 15(1):53. https://doi.org/10.3390/cancers15010053
Chicago/Turabian StyleChevreux, Steeve, Sandra de Barros, Camille Laurent, Amandine Durand, Cyrille Delpierre, Philippine Robert, Clémentine Joubert, Samuel Griolet, Salim Kanoun, Jean-Noël Bastie, and et al. 2023. "Influence of Sociodemographic Determinants on the Hodgkin Lymphoma Baseline Characteristics in Long Survivors Patients Enrolled in the Prospective Phase 3 Trial AHL2011" Cancers 15, no. 1: 53. https://doi.org/10.3390/cancers15010053