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Review
Peer-Review Record

HER3 Alterations in Cancer and Potential Clinical Implications

Cancers 2022, 14(24), 6174; https://doi.org/10.3390/cancers14246174
by Mary Kate Kilroy 1, SoYoung Park 1,2, Wasim Feroz 1, Hima Patel 3, Rosalin Mishra 1, Samar Alanazi 1 and Joan T. Garrett 1,*
Reviewer 1:
Reviewer 2:
Cancers 2022, 14(24), 6174; https://doi.org/10.3390/cancers14246174
Submission received: 13 November 2022 / Revised: 9 December 2022 / Accepted: 12 December 2022 / Published: 14 December 2022

Round 1

Reviewer 1 Report

This is well constructed and interesting review. My main comment is that the figure legends could be improved:

1) Figure 1 - Label the domains. Include a key in the legend to define symbols including the star, P, NRG, colour code. 

2) Figure 3, 4, 5 and 6 - Increase the size so that the domain labels are readable. Include a key to the coloured dots in the figure legend. 

3) Figure 7 - Expand the legend. Include key to colour and symbol code.

Author Response

Please see attached document.

Author Response File: Author Response.pdf

Reviewer 2 Report

This article provides a comprehensive description of HER3, the molecule, its role in various cancers, and the utility of targeted therapy in these cancers. it may be helpful to understand that HER3 is a therapeutic target in cancer.

Author Response

Please see attached document.

Author Response File: Author Response.pdf

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